Genomic landscape and molecularly informed therapy in thymic carcinoma and other advanced thymic epithelial tumors.

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Title: Genomic landscape and molecularly informed therapy in thymic carcinoma and other advanced thymic epithelial tumors.
Authors: Möhrmann L; Computational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, USA; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), NCT Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; Translational Medical Oncology, Faculty of Medicine, and University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany. Electronic address: lino.moehrmann@nct-dresden.de., Rostock L; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), NCT Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany., Werner M; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), NCT Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; Translational Medical Oncology, Faculty of Medicine, and University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany., Oleś M; Computational Oncology Group (CO), Molecular Precision Oncology Program (MPOP), German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Arnold JS; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), NCT Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; Translational Medical Oncology, Faculty of Medicine, and University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany; Institute for Clinical Genetics, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; ERN GENTURIS, Hereditary Cancer Syndrome Center Dresden, Dresden, Germany; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Paramasivam N; Computational Oncology Group (CO), Molecular Precision Oncology Program (MPOP), German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Jöhrens K; Department of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany., Rupp L; Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany., Schmitz M; Institute of Immunology, Faculty of Medicine Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany., Richter D; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), NCT Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany., Uhrig S; Computational Oncology Group (CO), Molecular Precision Oncology Program (MPOP), German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Fröhlich M; Computational Oncology Group (CO), Molecular Precision Oncology Program (MPOP), German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Hutter B; Computational Oncology Group (CO), Molecular Precision Oncology Program (MPOP), German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Hüllein J; Computational Oncology Group (CO), Molecular Precision Oncology Program (MPOP), German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Jahn A; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), NCT Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; Translational Medical Oncology, Faculty of Medicine, and University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany; Institute for Clinical Genetics, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; ERN GENTURIS, Hereditary Cancer Syndrome Center Dresden, Dresden, Germany; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Arlt M; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), NCT Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; Translational Medical Oncology, Faculty of Medicine, and University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany; Institute for Clinical Genetics, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; ERN GENTURIS, Hereditary Cancer Syndrome Center Dresden, Dresden, Germany; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Möhrmann EE; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), NCT Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; Translational Medical Oncology, Faculty of Medicine, and University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany., Hanf D; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), NCT Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; Translational Medical Oncology, Faculty of Medicine, and University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany., Gieldon L; Institute of Medical Genetics, Carl von Ossietzky University, Oldenburg, Germany., Kreutzfeldt S; Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany; NCT Heidelberg, Heidelberg, Germany., Heilig CE; Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany; NCT Heidelberg, Heidelberg, Germany., Teleanu MV; Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany; NCT Heidelberg, Heidelberg, Germany., Lipka DB; Section Translational Cancer Epigenomics, Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany., Beck K; Institute of Medical Genetics, Carl von Ossietzky University, Oldenburg, Germany., Baude-Müller A; Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany; NCT Heidelberg, Heidelberg, Germany; Section Translational Cancer Epigenomics, Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany., Mock A; Institute of Pathology, Ludwig-Maximilians-Universität München (LMU), Munich, Germany., Jelas I; Charité Comprehensive Cancer Center, Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Rieke DT; Charité Comprehensive Cancer Center, Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Wiesweg M; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany., Brandts C; Department of Medicine, Hematology/Oncology, University Hospital, Goethe University, Frankfurt, Germany; University Cancer Center Frankfurt (UCT), University Hospital, Goethe University, Frankfurt, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany., Boerries M; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, and Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Illert AL; Department of Internal Medicine I, Division of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg im Breisgau, Germany; Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Desuki A; University Cancer Center and Department of Internal Medicine III, University Medical Center Mainz, Mainz, Germany; TRON-Translational Oncology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany; DKTK, partner site Frankfurt/Mainz, a partnership between DKFZ and University Medical Center Mainz, Mainz, Germany., Kindler T; University Cancer Center and Department of Internal Medicine III, University Medical Center Mainz, Mainz, Germany; TRON-Translational Oncology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany; DKTK, partner site Frankfurt/Mainz, a partnership between DKFZ and University Medical Center Mainz, Mainz, Germany., Krackhardt AM; Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Westphalen CB; Department of Internal Medicine III, University Hospital, LMU Munich and Comprehensive Cancer Center, Munich, Germany., Christopoulos P; Department of Thoracic Oncology, Thoraxklinik, Heidelberg University Hospital, and NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany; Translational Lung Research Center, member of the German Center for Lung Research (DZL), Heidelberg, Germany., Apostolidis L; Department of Medical Oncology, NCT Heidelberg and Heidelberg University Hospital, Heidelberg, Germany., Stenzinger A; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Allgäuer M; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Neumann O; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Kerle IA; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), NCT Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; Translational Medical Oncology, Faculty of Medicine, and University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany., Horak P; Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany; NCT Heidelberg, Heidelberg, Germany., Heining C; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), NCT Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; Translational Medical Oncology, Faculty of Medicine, and University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany., Grosch H; Department of Thoracic Oncology, Thoraxklinik, Heidelberg University Hospital, and NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany; Translational Lung Research Center, member of the German Center for Lung Research (DZL), Heidelberg, Germany., Schröck E; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), NCT Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; Translational Medical Oncology, Faculty of Medicine, and University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany; Institute for Clinical Genetics, University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; ERN GENTURIS, Hereditary Cancer Syndrome Center Dresden, Dresden, Germany; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Hübschmann D; Computational Oncology Group (CO), Molecular Precision Oncology Program (MPOP), German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany; Innovation and Service Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany; Pattern Recognition and Digital Medicine Group, Heidelberg Institute for Stem cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany., Fröhling S; Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany; NCT Heidelberg, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany., Glimm H; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT), NCT Dresden, a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; Translational Medical Oncology, Faculty of Medicine, and University Hospital Carl Gustav Carus, TU Dresden University of Technology, Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany; Translational Functional Cancer Genomics, DKFZ Heidelberg, Heidelberg, Germany. Electronic address: hanno.glimm@nct-dresden.de.
Source: Med (New York, N.Y.) [Med] 2025 Jun 13; Vol. 6 (6), pp. 100612. Date of Electronic Publication: 2025 Mar 18.
Publication Type: Journal Article; Observational Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101769215 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-6340 (Electronic) Linking ISSN: 26666340 NLM ISO Abbreviation: Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-6340
DOI:10.1016/j.medj.2025.100612