Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk.
Saved in:
| Title: | Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk. |
|---|---|
| Authors: | Georgakis MK; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Feodor-Lynen-Str. 17, 81377, Munich, Germany. marios.georgakis@med.uni-muenchen.de.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. marios.georgakis@med.uni-muenchen.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. marios.georgakis@med.uni-muenchen.de., Malik R; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Feodor-Lynen-Str. 17, 81377, Munich, Germany., Bounkari OE; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Feodor-Lynen-Str. 17, 81377, Munich, Germany., Hasbani NR; Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, the University of Texas Health Science Center at Houston, Houston, TX, USA., Li J; Department of Molecular and Functional Genomics, Geisinger Health System, Danville, PA, USA., Huffman JE; Veterans Affairs Healthcare System, Boston, MA, USA., Shakt G; Department of Surgery, Perelman School of Medicineat Theaq , University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA., Tack RWP; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Kimball TN; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Asare Y; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Feodor-Lynen-Str. 17, 81377, Munich, Germany., Morrison AC; Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, the University of Texas Health Science Center at Houston, Houston, TX, USA., Tsao NL; Department of Surgery, Perelman School of Medicineat Theaq , University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA., Judy R; Department of Surgery, Perelman School of Medicineat Theaq , University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Xu H; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Montasser ME; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Do R; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kenny EE; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Terry JG; Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA., Carr JJ; Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA., Bis JC; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Psaty BM; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Longstreth WT; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Neurology, University of Washington, Seattle, WA, USA., Young KA; Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Lutz SM; Department of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Pilgrim Health Careand, Harvard Medical School , Boston, MA, USA.; Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Cho MH; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Broome J; Department of Biostatistics, University of Washington, Seattle, WA, USA., Khan AT; Department of Biostatistics, University of Washington, Seattle, WA, USA., Wang FF; Department of Biostatistics, University of Washington, Seattle, WA, USA., Heard-Costa N; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Boston University and National Heart, Blood Institute'S Framingham Heart Study, Lung, and Framingham, MA, USA., Seshadri S; Bigg'S Institute for Alzheimer'S Disease and Neurodegenerative Disorders, University of Texas Health Science Center, San Antonio, TX, USA., Vasan RS; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Boston University and National Heart, Blood Institute'S Framingham Heart Study, Lung, and Framingham, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Freedman BI; Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kral BG; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Becker LC; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Ammous F; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Carson AP; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Hall ME; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Post WS; Johns Hopkins Bloomberg School of Public Health, Johns Hopkins School of Medicine, Baltimore, MD, USA., Tracy RP; Departments of Pathology & Laboratory Medicine, and Biochemistry, Larner College of Medicine, University of Vermont, Burlington, VT, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Mahaney MC; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Clarke SL; Department of Medicine (Division of Cardiovascular Medicine), Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA., Haessler JW; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA., Hu Y; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA., Assimes TL; Department of Medicine (Division of Cardiovascular Medicine), Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA., Bernhagen J; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Feodor-Lynen-Str. 17, 81377, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; German Centre for Cardiovascular Research (DZHK, Munich), Partner Site Munich Heart Alliance, Munich, Germany., Anderson CD; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Damrauer SM; Department of Surgery, Perelman School of Medicineat Theaq , University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Genetics, Perelman School of Medicineat the , University of Pennsylvania, Philadelphia, PA, USA., Zand R; Department of Neurology, Pennsylvania State University, Hershey, PA, USA.; Department of Neurology, Neuroscience Institute, Geisinger Health System, Danville, PA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., de Vries PS; Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, the University of Texas Health Science Center at Houston, Houston, TX, USA., Dichgans M; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Feodor-Lynen-Str. 17, 81377, Munich, Germany. martin.dichgans@med.uni-muenchen.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. martin.dichgans@med.uni-muenchen.de.; German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany. martin.dichgans@med.uni-muenchen.de.; German Centre for Cardiovascular Research (DZHK, Munich), Partner Site Munich Heart Alliance, Munich, Germany. martin.dichgans@med.uni-muenchen.de. |
| Source: | Genome medicine [Genome Med] 2025 Mar 21; Vol. 17 (1), pp. 27. Date of Electronic Publication: 2025 Mar 21. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| ISSN: | 1756-994X |
|---|---|
| DOI: | 10.1186/s13073-025-01456-2 |
