Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate.

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Title: Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate.
Authors: Zuo P; Institute of Systems Biomedicine, Department of Pathology, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China., Wang W; Institute of Systems Biomedicine, Department of Pathology, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China., Dai Z; Institute of Systems Biomedicine, Department of Pathology, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China., Zheng J; Department of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China., Yu S; Department of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China., Wang G; Institute of Systems Biomedicine, Department of Pathology, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China., Yin Y; Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China., Liang L; Institute of Systems Biomedicine, Department of Pathology, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China. liangling@hsc.pku.edu.cn.; Department of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China. liangling@hsc.pku.edu.cn., Yin Y; Institute of Systems Biomedicine, Department of Pathology, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China. yinyuxin@hsc.pku.edu.cn.; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. yinyuxin@hsc.pku.edu.cn.; Institute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen, China. yinyuxin@hsc.pku.edu.cn.
Source: Nature communications [Nat Commun] 2025 Mar 24; Vol. 16 (1), pp. 2879. Date of Electronic Publication: 2025 Mar 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-58200-y