Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy.

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Bibliographic Details
Title: Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy.
Authors: Wolf CM; Department of Congenital Heart Defects and Pediatric Cardiology, German Heart Center Munich, School of Medicine and Health, Technical University of Munich, Munich, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Member of the European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart., Zenker M; Institute of Human Genetics, University Hospital Magdeburg, Otto-von-Guericke-University, Magdeburg, Germany., Boleti O; Centre for Inherited Cardiovascular Diseases, Institute of Cardiovascular Science, University College London and Great Ormond Street Hospital, London, United Kingdom., Norrish G; Centre for Inherited Cardiovascular Diseases, Institute of Cardiovascular Science, University College London and Great Ormond Street Hospital, London, United Kingdom., Russell M; University of Michigan, Ann Arbor, Michigan, USA., Meisner JK; University of Michigan, Ann Arbor, Michigan, USA., Peng DM; University of Michigan, Ann Arbor, Michigan, USA., Prendiville T; Children's Health Ireland at Crumlin, Crumlin, Ireland., Kleinmahon J; Ochsner Hospital for Children, Jefferson, Louisiana, USA., Kantor PF; Children's Hospital Los Angeles, Los Angeles, California, USA., Gottlieb Sen D; Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Human DG; British Columbia's Children's Hospital, Vancouver, British Columbia, Canada., Ewert P; Department of Congenital Heart Defects and Pediatric Cardiology, German Heart Center Munich, School of Medicine and Health, Technical University of Munich, Munich, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Member of the European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart., Krueger M; Department of Neonatology, Municipal Hospital Munich Schwabing, Munich, Germany., Reber D; Department of Neonatology, Municipal Hospital Munich Schwabing, Munich, Germany., Donner B; Pediatric Cardiology, University Children's Hospital of Basel, University of Basel, Basel, Switzerland., Hart C; Department of Pediatric Cardiology, Pediatric Heart Center, Children's Hospital, University of Bonn, Bonn, Germany., Odri Komazec I; Department of Child and Adolescent Health (Pediatrics III, Pediatric Cardiology), Medical University of Innsbruck, Innsbruck, Austria., Rupp S; Pediatric Heart Center, University of Giessen and Marburg, Giessen, Germany., Hahn A; Department of Child Neurology, University of Giessen, Giessen, Germany., Hanser A; Department of Pediatric Cardiology and Intensive Medicine, University Hospital Tübingen, Eberhard-Karls-University, Tübingen, Germany., Hofbeck M; Department of Pediatric Cardiology and Intensive Medicine, University Hospital Tübingen, Eberhard-Karls-University, Tübingen, Germany., Draaisma JMT; Radboud University Medical Center, Radboud Institute for Health Sciences, Amalia Children's Hospital, Department of Pediatrics, Nijmegen, the Netherlands., Udink Ten Cate FEA; Radboud University Medical Center, Radboud Institute for Health Sciences, Amalia Children's Hospital, Department of Pediatrics, Nijmegen, the Netherlands., Mussa A; Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy., Ferrero GB; Department of Clinical and Biological Sciences, School of Medicine, University of Turin, Turin, Italy., Vaujois L; Centre Mère-Enfant Soleil, Université de Laval, Quebec City, Quebec, Canada., Raboisson MJ; CHU Sainte Justine, Department of Pediatrics, Université de Montréal, Montréal, Quebec, Canada., Delrue MA; CHU Sainte Justine, Department of Pediatrics, Université de Montréal, Montréal, Quebec, Canada., Marquis C; CHU Sainte Justine, Department of Pediatrics, Université de Montréal, Montréal, Quebec, Canada., Théoret Y; CHU Sainte Justine, Department of Pediatrics, Université de Montréal, Montréal, Quebec, Canada., Bogarapu S; Children's Hospital of Illinois, University of Illinois College of Medicine, Chicago, Illinois, USA., Dancea A; Montreal Children's Hospital, McGill University Health Center, Montréal, Quebec, Canada., Handrup MM; Member of the European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart; Center for Rare Diseases, Aarhus University Hospital, Copenhagen, Denmark., Kemna M; Seattle Children's Hospital, Seattle, Washington, USA., Ojala T; Member of the European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart; New Children's Hospital Pediatric Research Center, Helsinki University Hospital, Helsinki, Finland., Dham N; George Washington University and Children's National Hospital, Washington, District of Columbia, USA., Dicke F; Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada., Friede T; University Medical Center Göttingen, Department of Medical Statistics, Göttingen, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung (German Center for Cardiovascular Research), partner site Lower Saxony, Göttingen, Germany; Deutsches Zentrum für Kinder- und Jugendgesundheit (German Center for Child and Adolescent Health), partner site Göttingen, Göttingen, Germany., Kaski JP; Centre for Inherited Cardiovascular Diseases, Institute of Cardiovascular Science, University College London and Great Ormond Street Hospital, London, United Kingdom., Gelb BD; Mindich Child Health and Development Institute and Departments of Pediatrics and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Andelfinger G; CHU Sainte Justine, Department of Pediatrics, Université de Montréal, Montréal, Quebec, Canada. Electronic address: gregor.andelfinger.med@ssss.gouv.qc.ca.
Source: JACC. Basic to translational science [JACC Basic Transl Sci] 2025 Feb; Vol. 10 (2), pp. 152-166. Date of Electronic Publication: 2024 Dec 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2452-302X
DOI:10.1016/j.jacbts.2024.10.002