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Missense variants in FRS3 affect body mass index in populations of diverse ancestries.

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Title: Missense variants in FRS3 affect body mass index in populations of diverse ancestries.
Authors: Jonsdottir AB; deCODE genetics/Amgen Inc., Reykjavik, Iceland. andrea.jonsdottir@decode.is.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. andrea.jonsdottir@decode.is., Sveinbjornsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Thorolfsdottir RB; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Tamlander M; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland., Tragante V; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Olafsdottir T; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Rognvaldsson S; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Sigurdsson A; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Eggertsson HP; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Aegisdottir HM; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Arnar DO; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Division of Cardiology, Cardiovascular Services, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland., Banasik K; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Beyter D; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Bjarnason RG; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Children's Medical Center, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland., Bjornsdottir G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Brunak S; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Topholm Bruun M; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Dowsett J; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Einarsson E; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Einarsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Fridriksdottir R; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Ghouse J; Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Gretarsdottir S; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Halldorsson GH; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Helgadottir A; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Holm PC; The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ivarsdottir EV; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Iversen KK; Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark., Jensen BA; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Jonsdottir I; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Knight S; Intermountain Medical Center, Intermountain Heart Institute, Salt Lake City, UT, USA., Knowlton KU; Intermountain Medical Center, Intermountain Heart Institute, Salt Lake City, UT, USA.; School of Medicine, University of Utah, Salt Lake City, UT, USA., Kristmundsdottir S; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Larusdottir AE; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Magnusson OT; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Masson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Melsted P; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Mikkelsen C; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Moore KHS; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Oddsson A; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Olason PI; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Palsson F; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Pedersen OB; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Schwinn M; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Sigurdsson EL; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Development Centre for Primary Healthcare in Iceland, Primary Health Care of the Capital Area, Reykjavik, Iceland., Skaftason A; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Stefansdottir L; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Stefansson H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Steingrimsdottir T; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.; Department of Obstetrics and Gynecology, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland., Sturluson A; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Styrkarsdottir U; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Teitsdottir UD; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Thorgeirsson TE; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Thorisson GA; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Thorsteinsdottir U; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Ulfarsson MO; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Electrical and Computer Engineering, University of Iceland, Reykjavik, Iceland., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Vikingsson A; Department of Medicine, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland., Walters GB; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Nadauld LD; Precision Genomics, Intermountain Healthcare, Saint George, UT, USA., Bundgaard H; Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Helgason A; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Department of Anthropology, University of Iceland, Reykjavik, Iceland., Halldorsson BV; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Technology, Reykjavik University, Reykjavik, Iceland., Norddahl GL; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Ripatti S; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, Clinicum, University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gudbjartsson DF; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Thorleifsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Steinthorsdottir V; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Holm H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Sulem P; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland. kstefans@decode.is.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. kstefans@decode.is.
Corporate Authors: DBDS Genomic Consortium
Source: Nature communications [Nat Commun] 2025 Mar 25; Vol. 16 (1), pp. 2694. Date of Electronic Publication: 2025 Mar 25.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-57753-2