Effects of KCNQ potassium channel modulation on ventral tegmental area activity and connectivity in individuals with depression and anhedonia.

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Title: Effects of KCNQ potassium channel modulation on ventral tegmental area activity and connectivity in individuals with depression and anhedonia.
Authors: Morris LS; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA. laurel.morris@mssm.edu., Costi S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK., Hameed S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA., Collins KA; Nathan Kline Institute, Orangeburg, NY, USA., Stern ER; Nathan Kline Institute, Orangeburg, NY, USA.; New York University Grossman School of Medicine, New York, NY, USA., Chowdhury A; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA., Morel C; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, USA., Salas R; Menninger Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.; The Menninger Clinic, Houston, TX, USA.; Neuroscience Department, Baylor College of Medicine, Houston, TX, USA.; Center for Translational Research on Inflammatory Diseases, Michael E. Debakey VA Medical Center, Houston, TX, USA., Iosifescu DV; Nathan Kline Institute, Orangeburg, NY, USA.; New York University Grossman School of Medicine, New York, NY, USA., Han MH; Department of Mental Health and Public Health, Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, PR China.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mathew SJ; Menninger Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.; The Menninger Clinic, Houston, TX, USA.; Michael E. Debakey VA Medical Center, Houston, TX, USA., Murrough JW; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA. james.murrough@mssm.edu.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, USA. james.murrough@mssm.edu.; VISN 2 Mental Illness Research, Education, and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, NY, USA. james.murrough@mssm.edu.
Source: Molecular psychiatry [Mol Psychiatry] 2025 Aug; Vol. 30 (8), pp. 3686-3694. Date of Electronic Publication: 2025 Mar 25.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-02957-7