The Drug Titration Paradox in the Presence of Intra-Individual Variation: Can we Estimate the True Concentration-Effect Relationship?
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| Title: | The Drug Titration Paradox in the Presence of Intra-Individual Variation: Can we Estimate the True Concentration-Effect Relationship? |
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| Authors: | Goulooze SC; LAP&P Consultants BV, Archimedesweg 31, 2333 CM, Leiden, The Netherlands. b.goulooze@lapp.nl.; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands. b.goulooze@lapp.nl., Krekels EHJ; Certara Inc, Princeton, New Jersey, USA.; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands., Knibbe CAJ; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.; Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands., van Noort M; LAP&P Consultants BV, Archimedesweg 31, 2333 CM, Leiden, The Netherlands. |
| Source: | The AAPS journal [AAPS J] 2025 Mar 26; Vol. 27 (3), pp. 70. Date of Electronic Publication: 2025 Mar 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1550-7416 |
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| DOI: | 10.1208/s12248-025-01055-4 |
