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The Drug Titration Paradox in the Presence of Intra-Individual Variation: Can we Estimate the True Concentration-Effect Relationship?

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Title: The Drug Titration Paradox in the Presence of Intra-Individual Variation: Can we Estimate the True Concentration-Effect Relationship?
Authors: Goulooze SC; LAP&P Consultants BV, Archimedesweg 31, 2333 CM, Leiden, The Netherlands. b.goulooze@lapp.nl.; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands. b.goulooze@lapp.nl., Krekels EHJ; Certara Inc, Princeton, New Jersey, USA.; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands., Knibbe CAJ; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.; Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands., van Noort M; LAP&P Consultants BV, Archimedesweg 31, 2333 CM, Leiden, The Netherlands.
Source: The AAPS journal [AAPS J] 2025 Mar 26; Vol. 27 (3), pp. 70. Date of Electronic Publication: 2025 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Goulooze+SC%22">Goulooze SC</searchLink>; LAP&P Consultants BV, Archimedesweg 31, 2333 CM, Leiden, The Netherlands. b.goulooze@lapp.nl.; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands. b.goulooze@lapp.nl.<br /><searchLink fieldCode="AU" term="%22Krekels+EHJ%22">Krekels EHJ</searchLink>; Certara Inc, Princeton, New Jersey, USA.; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Knibbe+CAJ%22">Knibbe CAJ</searchLink>; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.; Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Noort+M%22">van Noort M</searchLink>; LAP&P Consultants BV, Archimedesweg 31, 2333 CM, Leiden, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101223209%22">The AAPS journal</searchLink> [AAPS J] 2025 Mar 26; Vol. 27 (3), pp. 70. <i>Date of Electronic Publication: </i>2025 Mar 26.
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