Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: The FARES-II Multicenter Randomized Clinical Trial.
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| Title: | Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: The FARES-II Multicenter Randomized Clinical Trial. |
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| Authors: | Karkouti K; Department of Anesthesia and Pain Management, University Health Network, Sinai Health, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.; Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada., Callum JL; Department of Pathology and Molecular Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, Ontario, Canada.; Sunnybrook Research Institute, Toronto, Ontario, Canada., Bartoszko J; Department of Anesthesia and Pain Management, University Health Network, Sinai Health, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.; Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada., Tanaka KA; Department of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City., Knaub S; Octapharma AG, Lachen, Switzerland., Brar S; Department of Anesthesiology and Perioperative Medicine, Royal Columbian Hospital, Vancouver, British Columbia, Canada.; University of British Columbia, Vancouver, Canada., Ghadimi K; Clinical Research Unit, Department of Anesthesiology & Critical Care, Duke University Health System, Durham, North Carolina., Rochon A; Department of Anesthesia, University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada., Mullane D; Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Canada.; Vancouver General Hospital, Vancouver, British Columbia, Canada., Couture EJ; Department of Anesthesiology, Quebec Heart and Lung Institute, Laval University, Quebec, Quebec, Canada., Lin Y; Precision Diagnostics and Therapeutics Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Harle C; London Health Sciences Centre, London, Ontario, Canada.; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada., Zeller M; Micheal G. DeGroote Centre for Transfusion Research, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Canadian Blood Services, Ottawa, Ontario, Canada., Tran DTT; Division of Cardiac Anesthesiology and Critical Care, University of Ottawa Heart Institute, Ottawa, Ontario, Canada., Solomon C; Octapharma AG, Lachen, Switzerland., Rao V; Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Surgery, University of Toronto, Toronto, Ontario, Canada., Law M; Department of Anesthesiology and Perioperative Medicine, Royal Columbian Hospital, Vancouver, British Columbia, Canada.; University of British Columbia, Vancouver, Canada., Butt AL; Department of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City., Chen EP; Cardiothoracic Surgery Division, Department of Surgery, Duke University Health System, Durham, North Carolina., Martins MR; Department of Anesthesia, University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada., Saha T; Department of Anesthesiology and Perioperative Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, Ontario, Canada., Shih AW; Vancouver General Hospital, Vancouver, British Columbia, Canada.; Current affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton General Hospital, Hamilton, Ontario, Canada., Vézina MC; Department of Anesthesiology, Quebec Heart and Lung Institute, Laval University, Quebec, Quebec, Canada., Moussa F; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.; Division of Cardiac Surgery, Sunnybrook Health Sciences Centre, Schulich Heart Centre, Toronto, Ontario, Canada., Pereira Cezar Zamper R; London Health Sciences Centre, London, Ontario, Canada., Syed S; Department of Anesthesia, McMaster University, Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada.; Department of Anesthesia, Oakville Trafalgar Memorial Hospital, Oakville, Ontario, Canada., Buyukdere H; Division of Hematopathology and Transfusion Medicine, University of Ottawa, Ottawa, Ontario, Canada., Werner S; Octapharma USA Inc, Paramus, New Jersey., Grewal D; Department of Anesthesia and Pain Management, University Health Network, Sinai Health, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.; Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada., Wong D; Division of Cardiac Surgery, Royal Columbian Hospital, New Westminster, British Columbia, Canada.; Department of Surgery, University of British Columbia, Vancouver, Canada., Vandyck KB; Department of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City., Tanzola R; Department of Anesthesiology and Perioperative Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, Ontario, Canada., Hughes B; Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Canada.; Vancouver General Hospital, Vancouver, British Columbia, Canada., Royer O; Department of Anesthesiology, Quebec Heart and Lung Institute, Laval University, Quebec, Quebec, Canada., Wong S; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Levy JH; Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, North Carolina. |
| Corporate Authors: | FARES-II Study Group |
| Source: | JAMA [JAMA] 2025 May 27; Vol. 333 (20), pp. 1781-1792. |
| Publication Type: | Clinical Trial, Phase III; Comparative Study; Equivalence Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1538-3598 |
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| DOI: | 10.1001/jama.2025.3501 |
