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Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: The FARES-II Multicenter Randomized Clinical Trial.

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Title: Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: The FARES-II Multicenter Randomized Clinical Trial.
Authors: Karkouti K; Department of Anesthesia and Pain Management, University Health Network, Sinai Health, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.; Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada., Callum JL; Department of Pathology and Molecular Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, Ontario, Canada.; Sunnybrook Research Institute, Toronto, Ontario, Canada., Bartoszko J; Department of Anesthesia and Pain Management, University Health Network, Sinai Health, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.; Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada., Tanaka KA; Department of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City., Knaub S; Octapharma AG, Lachen, Switzerland., Brar S; Department of Anesthesiology and Perioperative Medicine, Royal Columbian Hospital, Vancouver, British Columbia, Canada.; University of British Columbia, Vancouver, Canada., Ghadimi K; Clinical Research Unit, Department of Anesthesiology & Critical Care, Duke University Health System, Durham, North Carolina., Rochon A; Department of Anesthesia, University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada., Mullane D; Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Canada.; Vancouver General Hospital, Vancouver, British Columbia, Canada., Couture EJ; Department of Anesthesiology, Quebec Heart and Lung Institute, Laval University, Quebec, Quebec, Canada., Lin Y; Precision Diagnostics and Therapeutics Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Harle C; London Health Sciences Centre, London, Ontario, Canada.; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada., Zeller M; Micheal G. DeGroote Centre for Transfusion Research, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Canadian Blood Services, Ottawa, Ontario, Canada., Tran DTT; Division of Cardiac Anesthesiology and Critical Care, University of Ottawa Heart Institute, Ottawa, Ontario, Canada., Solomon C; Octapharma AG, Lachen, Switzerland., Rao V; Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Surgery, University of Toronto, Toronto, Ontario, Canada., Law M; Department of Anesthesiology and Perioperative Medicine, Royal Columbian Hospital, Vancouver, British Columbia, Canada.; University of British Columbia, Vancouver, Canada., Butt AL; Department of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City., Chen EP; Cardiothoracic Surgery Division, Department of Surgery, Duke University Health System, Durham, North Carolina., Martins MR; Department of Anesthesia, University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada., Saha T; Department of Anesthesiology and Perioperative Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, Ontario, Canada., Shih AW; Vancouver General Hospital, Vancouver, British Columbia, Canada.; Current affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton General Hospital, Hamilton, Ontario, Canada., Vézina MC; Department of Anesthesiology, Quebec Heart and Lung Institute, Laval University, Quebec, Quebec, Canada., Moussa F; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.; Division of Cardiac Surgery, Sunnybrook Health Sciences Centre, Schulich Heart Centre, Toronto, Ontario, Canada., Pereira Cezar Zamper R; London Health Sciences Centre, London, Ontario, Canada., Syed S; Department of Anesthesia, McMaster University, Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada.; Department of Anesthesia, Oakville Trafalgar Memorial Hospital, Oakville, Ontario, Canada., Buyukdere H; Division of Hematopathology and Transfusion Medicine, University of Ottawa, Ottawa, Ontario, Canada., Werner S; Octapharma USA Inc, Paramus, New Jersey., Grewal D; Department of Anesthesia and Pain Management, University Health Network, Sinai Health, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.; Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada., Wong D; Division of Cardiac Surgery, Royal Columbian Hospital, New Westminster, British Columbia, Canada.; Department of Surgery, University of British Columbia, Vancouver, Canada., Vandyck KB; Department of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City., Tanzola R; Department of Anesthesiology and Perioperative Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, Ontario, Canada., Hughes B; Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Canada.; Vancouver General Hospital, Vancouver, British Columbia, Canada., Royer O; Department of Anesthesiology, Quebec Heart and Lung Institute, Laval University, Quebec, Quebec, Canada., Wong S; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.; Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Levy JH; Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, North Carolina.
Corporate Authors: FARES-II Study Group
Source: JAMA [JAMA] 2025 May 27; Vol. 333 (20), pp. 1781-1792.
Publication Type: Clinical Trial, Phase III; Comparative Study; Equivalence Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: The FARES-II Multicenter Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Karkouti+K%22">Karkouti K</searchLink>; Department of Anesthesia and Pain Management, University Health Network, Sinai Health, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.; Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Callum+JL%22">Callum JL</searchLink>; Department of Pathology and Molecular Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, Ontario, Canada.; Sunnybrook Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bartoszko+J%22">Bartoszko J</searchLink>; Department of Anesthesia and Pain Management, University Health Network, Sinai Health, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.; Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tanaka+KA%22">Tanaka KA</searchLink>; Department of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City.<br /><searchLink fieldCode="AU" term="%22Knaub+S%22">Knaub S</searchLink>; Octapharma AG, Lachen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Brar+S%22">Brar S</searchLink>; Department of Anesthesiology and Perioperative Medicine, Royal Columbian Hospital, Vancouver, British Columbia, Canada.; University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Ghadimi+K%22">Ghadimi K</searchLink>; Clinical Research Unit, Department of Anesthesiology & Critical Care, Duke University Health System, Durham, North Carolina.<br /><searchLink fieldCode="AU" term="%22Rochon+A%22">Rochon A</searchLink>; Department of Anesthesia, University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Mullane+D%22">Mullane D</searchLink>; Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Canada.; Vancouver General Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Couture+EJ%22">Couture EJ</searchLink>; Department of Anesthesiology, Quebec Heart and Lung Institute, Laval University, Quebec, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Lin+Y%22">Lin Y</searchLink>; Precision Diagnostics and Therapeutics Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Harle+C%22">Harle C</searchLink>; London Health Sciences Centre, London, Ontario, Canada.; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zeller+M%22">Zeller M</searchLink>; Micheal G. DeGroote Centre for Transfusion Research, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Canadian Blood Services, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tran+DTT%22">Tran DTT</searchLink>; Division of Cardiac Anesthesiology and Critical Care, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Solomon+C%22">Solomon C</searchLink>; Octapharma AG, Lachen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rao+V%22">Rao V</searchLink>; Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Law+M%22">Law M</searchLink>; Department of Anesthesiology and Perioperative Medicine, Royal Columbian Hospital, Vancouver, British Columbia, Canada.; University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Butt+AL%22">Butt AL</searchLink>; Department of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City.<br /><searchLink fieldCode="AU" term="%22Chen+EP%22">Chen EP</searchLink>; Cardiothoracic Surgery Division, Department of Surgery, Duke University Health System, Durham, North Carolina.<br /><searchLink fieldCode="AU" term="%22Martins+MR%22">Martins MR</searchLink>; Department of Anesthesia, University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Saha+T%22">Saha T</searchLink>; Department of Anesthesiology and Perioperative Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Shih+AW%22">Shih AW</searchLink>; Vancouver General Hospital, Vancouver, British Columbia, Canada.; Current affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton General Hospital, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Vézina+MC%22">Vézina MC</searchLink>; Department of Anesthesiology, Quebec Heart and Lung Institute, Laval University, Quebec, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Moussa+F%22">Moussa F</searchLink>; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.; Division of Cardiac Surgery, Sunnybrook Health Sciences Centre, Schulich Heart Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Pereira+Cezar+Zamper+R%22">Pereira Cezar Zamper R</searchLink>; London Health Sciences Centre, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Syed+S%22">Syed S</searchLink>; Department of Anesthesia, McMaster University, Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada.; Department of Anesthesia, Oakville Trafalgar Memorial Hospital, Oakville, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Buyukdere+H%22">Buyukdere H</searchLink>; Division of Hematopathology and Transfusion Medicine, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Werner+S%22">Werner S</searchLink>; Octapharma USA Inc, Paramus, New Jersey.<br /><searchLink fieldCode="AU" term="%22Grewal+D%22">Grewal D</searchLink>; Department of Anesthesia and Pain Management, University Health Network, Sinai Health, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.; Peter Munk Cardiac Centre and Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wong+D%22">Wong D</searchLink>; Division of Cardiac Surgery, Royal Columbian Hospital, New Westminster, British Columbia, Canada.; Department of Surgery, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Vandyck+KB%22">Vandyck KB</searchLink>; Department of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City.<br /><searchLink fieldCode="AU" term="%22Tanzola+R%22">Tanzola R</searchLink>; Department of Anesthesiology and Perioperative Medicine, Kingston Health Sciences Centre and Queen's University, Kingston, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hughes+B%22">Hughes B</searchLink>; 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