Targeted Normoxemia and Supplemental Oxygen-Free Days in Critically Injured Adults: A Stepped-Wedge Cluster Randomized Clinical Trial.

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Title: Targeted Normoxemia and Supplemental Oxygen-Free Days in Critically Injured Adults: A Stepped-Wedge Cluster Randomized Clinical Trial.
Authors: Douin DJ; Department of Anesthesiology, University of Colorado School of Medicine, Aurora., Rice JD; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor., Anderson EL; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora., Jackson CL; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora., Cheng AC; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Xiao M; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora., Cwik J; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora., Beaty LE; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora., Wild JL; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora., Daya MR; Department of Emergency Medicine, Oregon Health & Science University, Portland., Doshi PB; Department of Emergency Medicine, McGovern Medical School at The University of Texas Health Science Center, Houston., Eastham SC; Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee., Goodman MD; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio., Gunn SR; Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania., Haukoos JS; Department of Emergency Medicine, Denver Health Medical Center, Denver, Colorado., Hudson JA; Department of Emergency Medicine, McGovern Medical School at The University of Texas Health Science Center, Houston., Jansen JO; Department of Surgery, University of Alabama at Birmingham, Birmingham., McMullan JT; Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio., Rizzo JA; Department of Surgery, Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, San Antonio, Texas., Schreiber MA; Donald D. Trunkey Center for Civilian and Combat Casualty Care, Oregon Health & Science University, Portland., Self WH; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Semler MW; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Steinwand A; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora., Werner N; Department of Surgery, Denver Health Medical Center, Denver, Colorado.; Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison., Bebarta VS; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora.; Center for Combat Medicine and Battlefield Research, University of Colorado School of Medicine, Aurora., Schauer SG; US Army Institute of Surgical Research, Joint Base San Antonio-Fort Sam Houston, San Antonio, Texas.; Department of Emergency Medicine, Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, San Antonio, Texas., Ginde AA; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora.
Corporate Authors: Strategy to Avoid Excessive Oxygen (SAVE-O2) Investigators
Source: JAMA network open [JAMA Netw Open] 2025 Mar 03; Vol. 8 (3), pp. e252093. Date of Electronic Publication: 2025 Mar 03.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2574-3805
DOI:10.1001/jamanetworkopen.2025.2093