Multilayered HIV-1 resistance in HSPCs through CCR5 Knockout and B cell secretion of HIV-inhibiting antibodies.

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Title: Multilayered HIV-1 resistance in HSPCs through CCR5 Knockout and B cell secretion of HIV-inhibiting antibodies.
Authors: Feist WN; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Luna SE; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Medical Scientist Training Program, Stanford University School of Medicine, Stanford, CA, USA., Ben-Efraim K; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Filsinger Interrante MV; Stanford Medical Scientist Training Program, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Biophysics Program, Stanford University School of Medicine, Stanford, CA, USA.; Stanford ChEM-H, Stanford University, Stanford, CA, USA., Amorin A; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Medical Scientist Training Program, Stanford University School of Medicine, Stanford, CA, USA., Johnston NM; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Bruun TUJ; Stanford ChEM-H, Stanford University, Stanford, CA, USA.; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA., Utz A; Stanford Medical Scientist Training Program, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Biophysics Program, Stanford University School of Medicine, Stanford, CA, USA., Ghanim HY; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Lesch BJ; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.; Eli and Edythe Broad Center for Regeneration Medicine, University of California, San Francisco, San Francisco, CA, USA., McLaughlin TM; Stanford University Mass Spectrometry, Stanford University, Stanford, CA, USA., Dudek AM; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. amanda-dudek@uiowa.edu.; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. amanda-dudek@uiowa.edu., Porteus MH; Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. mporteus@stanford.edu.; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. mporteus@stanford.edu.
Source: Nature communications [Nat Commun] 2025 Apr 01; Vol. 16 (1), pp. 3103. Date of Electronic Publication: 2025 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-58371-8