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Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail.

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Title: Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail.
Authors: Breault É; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12è avenue nord, Sherbrooke, QC, J1H5N4, Canada.; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada., Brouillette RL; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12è avenue nord, Sherbrooke, QC, J1H5N4, Canada.; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada., Hébert TE; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada., Sarret P; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12è avenue nord, Sherbrooke, QC, J1H5N4, Canada. philippe.sarret@usherbrooke.ca.; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada. philippe.sarret@usherbrooke.ca.; RECITAL International Partnership Lab, Université de Caen-Normandie & Université de Sherbrooke, Caen, France. philippe.sarret@usherbrooke.ca., Besserer-Offroy É; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12è avenue nord, Sherbrooke, QC, J1H5N4, Canada. elie.besserer-offroy@inserm.fr.; RECITAL International Partnership Lab, Université de Caen-Normandie & Université de Sherbrooke, Caen, France. elie.besserer-offroy@inserm.fr.; Université de Caen Normandie, INSERM U1086 - Anticipe, 3 avenue général Harris, BP 45026, 14076, Caen Cedex 5, France. elie.besserer-offroy@inserm.fr.; Baclesse Comprehensive Cancer Center, UNICANCER, Caen, France. elie.besserer-offroy@inserm.fr.
Source: CNS drugs [CNS Drugs] 2025 Jun; Vol. 39 (6), pp. 565-581. Date of Electronic Publication: 2025 Apr 01.
Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9431220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1934 (Electronic) Linking ISSN: 11727047 NLM ISO Abbreviation: CNS Drugs Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail.
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  Data: <searchLink fieldCode="AU" term="%22Breault+É%22">Breault É</searchLink>; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12è avenue nord, Sherbrooke, QC, J1H5N4, Canada.; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Brouillette+RL%22">Brouillette RL</searchLink>; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12è avenue nord, Sherbrooke, QC, J1H5N4, Canada.; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Hébert+TE%22">Hébert TE</searchLink>; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Sarret+P%22">Sarret P</searchLink>; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12è avenue nord, Sherbrooke, QC, J1H5N4, Canada. philippe.sarret@usherbrooke.ca.; Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada. philippe.sarret@usherbrooke.ca.; RECITAL International Partnership Lab, Université de Caen-Normandie & Université de Sherbrooke, Caen, France. philippe.sarret@usherbrooke.ca.<br /><searchLink fieldCode="AU" term="%22Besserer-Offroy+É%22">Besserer-Offroy É</searchLink>; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12è avenue nord, Sherbrooke, QC, J1H5N4, Canada. elie.besserer-offroy@inserm.fr.; RECITAL International Partnership Lab, Université de Caen-Normandie & Université de Sherbrooke, Caen, France. elie.besserer-offroy@inserm.fr.; Université de Caen Normandie, INSERM U1086 - Anticipe, 3 avenue général Harris, BP 45026, 14076, Caen Cedex 5, France. elie.besserer-offroy@inserm.fr.; Baclesse Comprehensive Cancer Center, UNICANCER, Caen, France. elie.besserer-offroy@inserm.fr.
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  Data: <searchLink fieldCode="JN" term="%229431220%22">CNS drugs</searchLink> [CNS Drugs] 2025 Jun; Vol. 39 (6), pp. 565-581. <i>Date of Electronic Publication: </i>2025 Apr 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Adis%2C+Springer+International%22">Adis, Springer International </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>9431220 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1179-1934 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211727047%22">11727047 </searchLink><i>NLM ISO Abbreviation: </i>CNS Drugs <i>Subsets: </i>MEDLINE
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              Text: 2025 Jun
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