Clinically relevant clot resolution via a thromboinflammation-on-a-chip.

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Title: Clinically relevant clot resolution via a thromboinflammation-on-a-chip.
Authors: Qiu Y; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA. yongzhi.qiu@emory.edu.; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA. yongzhi.qiu@emory.edu.; Winship Cancer Institute of Emory University, Atlanta, GA, USA. yongzhi.qiu@emory.edu.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA. yongzhi.qiu@emory.edu.; The Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA, USA. yongzhi.qiu@emory.edu., Lin J; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.; Winship Cancer Institute of Emory University, Atlanta, GA, USA.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.; The Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA, USA., Wang A; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.; Winship Cancer Institute of Emory University, Atlanta, GA, USA.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.; The Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA, USA., Fang Z; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA., Sakurai Y; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.; Winship Cancer Institute of Emory University, Atlanta, GA, USA.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.; The Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA, USA., Choi H; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.; Winship Cancer Institute of Emory University, Atlanta, GA, USA.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.; The Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA, USA., Williams EK; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.; Winship Cancer Institute of Emory University, Atlanta, GA, USA.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.; The Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA, USA., Hardy ET; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.; Winship Cancer Institute of Emory University, Atlanta, GA, USA.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.; The Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA, USA., Maher K; Division of Hematology, Oncology, Bone Marrow Transplant, and Cellular Therapy, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA., Coskun AF; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA., Woods G; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA., Lam WA; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA. wilbur.lam@emory.edu.; Department of Pediatrics, Division of Pediatric Hematology/Oncology, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA. wilbur.lam@emory.edu.; Winship Cancer Institute of Emory University, Atlanta, GA, USA. wilbur.lam@emory.edu.; Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA. wilbur.lam@emory.edu.; The Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA, USA. wilbur.lam@emory.edu.
Source: Nature [Nature] 2025 May; Vol. 641 (8065), pp. 1298-1308. Date of Electronic Publication: 2025 Apr 02.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-025-08804-7