Adaptive adjustment of profile HMM significance thresholds improves functional and metabolic insights into microbial genomes.
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| Title: | Adaptive adjustment of profile HMM significance thresholds improves functional and metabolic insights into microbial genomes. |
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| Authors: | Kananen K; Department of Microbiology, The Ohio State University, Columbus, OH 43210, United States., Veseli I; Helmholtz Institute for Functional Marine Biodiversity, 26129 Oldenburg, Germany.; Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research, 27570 Bremerhaven, Germany., Quiles Pérez CJ; Department of Microbiology, The Ohio State University, Columbus, OH 43210, United States., Miller SE; Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA 02543, United States., Eren AM; Helmholtz Institute for Functional Marine Biodiversity, 26129 Oldenburg, Germany.; Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research, 27570 Bremerhaven, Germany.; Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA 02543, United States.; Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, 26129 Oldenburg, Germany.; Marine 'Omics Bridging Group, Max Planck Institute for Marine Microbiology, 28359 Bremen, Germany., Bradley PH; Department of Microbiology, The Ohio State University, Columbus, OH 43210, United States.; Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210, United States.; Center of Microbiome Science, The Ohio State University, Columbus, OH 43210, United States. |
| Source: | Bioinformatics advances [Bioinform Adv] 2025 Mar 21; Vol. 5 (1), pp. vbaf039. Date of Electronic Publication: 2025 Mar 21 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9918282081306676 Publication Model: eCollection Cited Medium: Internet ISSN: 2635-0041 (Electronic) Linking ISSN: 26350041 NLM ISO Abbreviation: Bioinform Adv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2635-0041 |
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| DOI: | 10.1093/bioadv/vbaf039 |
