A naturally selected αβ T cell receptor binds HLA-DQ2 molecules without co-contacting the presented peptide.

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Title: A naturally selected αβ T cell receptor binds HLA-DQ2 molecules without co-contacting the presented peptide.
Authors: Lim JJ; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Jones CM; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Loh TJ; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Dao HT; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Tran MT; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Tye-Din JA; Immunology Division, The Walter and Eliza Hall Institute, Parkville, VIC, Australia., La Gruta NL; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. nicole.la.gruta@monash.edu., Rossjohn J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. jamie.rossjohn@monash.edu.; Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK. jamie.rossjohn@monash.edu.
Source: Nature communications [Nat Commun] 2025 Apr 08; Vol. 16 (1), pp. 3330. Date of Electronic Publication: 2025 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-58690-w