Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.
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| Title: | Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor. |
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| Authors: | Lockbaum GJ; Accent Therapeutics, Lexington, MA, 02421, USA., Lynes MM; Accent Therapeutics, Lexington, MA, 02421, USA. mlynes@accenttx.com., Shen SA; Accent Therapeutics, Lexington, MA, 02421, USA., Liu J; Accent Therapeutics, Lexington, MA, 02421, USA., Holt N; Accent Therapeutics, Lexington, MA, 02421, USA., Nayak SP; Accent Therapeutics, Lexington, MA, 02421, USA., Knockenhauer KE; Accent Therapeutics, Lexington, MA, 02421, USA., Yao S; Accent Therapeutics, Lexington, MA, 02421, USA., Sickmier EA; Accent Therapeutics, Lexington, MA, 02421, USA., Raman A; Accent Therapeutics, Lexington, MA, 02421, USA., Wu J; Accent Therapeutics, Lexington, MA, 02421, USA., Case A; Accent Therapeutics, Lexington, MA, 02421, USA., Shehaj L; Accent Therapeutics, Lexington, MA, 02421, USA., Buker SM; Accent Therapeutics, Lexington, MA, 02421, USA., Grigoriu S; Accent Therapeutics, Lexington, MA, 02421, USA., Ribich S; Accent Therapeutics, Lexington, MA, 02421, USA., Blakemore SJ; Accent Therapeutics, Lexington, MA, 02421, USA., Sparling BA; Accent Therapeutics, Lexington, MA, 02421, USA., Duncan KW; Accent Therapeutics, Lexington, MA, 02421, USA., Copeland RA; Accent Therapeutics, Lexington, MA, 02421, USA., Silver SJ; Accent Therapeutics, Lexington, MA, 02421, USA., Boriack-Sjodin PA; Accent Therapeutics, Lexington, MA, 02421, USA. |
| Source: | Communications biology [Commun Biol] 2025 Apr 09; Vol. 8 (1), pp. 589. Date of Electronic Publication: 2025 Apr 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2399-3642 |
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| DOI: | 10.1038/s42003-025-08005-y |
