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Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.

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Title: Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.
Authors: Lockbaum GJ; Accent Therapeutics, Lexington, MA, 02421, USA., Lynes MM; Accent Therapeutics, Lexington, MA, 02421, USA. mlynes@accenttx.com., Shen SA; Accent Therapeutics, Lexington, MA, 02421, USA., Liu J; Accent Therapeutics, Lexington, MA, 02421, USA., Holt N; Accent Therapeutics, Lexington, MA, 02421, USA., Nayak SP; Accent Therapeutics, Lexington, MA, 02421, USA., Knockenhauer KE; Accent Therapeutics, Lexington, MA, 02421, USA., Yao S; Accent Therapeutics, Lexington, MA, 02421, USA., Sickmier EA; Accent Therapeutics, Lexington, MA, 02421, USA., Raman A; Accent Therapeutics, Lexington, MA, 02421, USA., Wu J; Accent Therapeutics, Lexington, MA, 02421, USA., Case A; Accent Therapeutics, Lexington, MA, 02421, USA., Shehaj L; Accent Therapeutics, Lexington, MA, 02421, USA., Buker SM; Accent Therapeutics, Lexington, MA, 02421, USA., Grigoriu S; Accent Therapeutics, Lexington, MA, 02421, USA., Ribich S; Accent Therapeutics, Lexington, MA, 02421, USA., Blakemore SJ; Accent Therapeutics, Lexington, MA, 02421, USA., Sparling BA; Accent Therapeutics, Lexington, MA, 02421, USA., Duncan KW; Accent Therapeutics, Lexington, MA, 02421, USA., Copeland RA; Accent Therapeutics, Lexington, MA, 02421, USA., Silver SJ; Accent Therapeutics, Lexington, MA, 02421, USA., Boriack-Sjodin PA; Accent Therapeutics, Lexington, MA, 02421, USA.
Source: Communications biology [Commun Biol] 2025 Apr 09; Vol. 8 (1), pp. 589. Date of Electronic Publication: 2025 Apr 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.
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  Data: <searchLink fieldCode="AU" term="%22Lockbaum+GJ%22">Lockbaum GJ</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Lynes+MM%22">Lynes MM</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA. mlynes@accenttx.com.<br /><searchLink fieldCode="AU" term="%22Shen+SA%22">Shen SA</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Holt+N%22">Holt N</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Nayak+SP%22">Nayak SP</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Knockenhauer+KE%22">Knockenhauer KE</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Yao+S%22">Yao S</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Sickmier+EA%22">Sickmier EA</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Raman+A%22">Raman A</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Case+A%22">Case A</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Shehaj+L%22">Shehaj L</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Buker+SM%22">Buker SM</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Grigoriu+S%22">Grigoriu S</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Ribich+S%22">Ribich S</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Blakemore+SJ%22">Blakemore SJ</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Sparling+BA%22">Sparling BA</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Duncan+KW%22">Duncan KW</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Copeland+RA%22">Copeland RA</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Silver+SJ%22">Silver SJ</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Boriack-Sjodin+PA%22">Boriack-Sjodin PA</searchLink>; Accent Therapeutics, Lexington, MA, 02421, USA.
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  Data: <searchLink fieldCode="JN" term="%22101719179%22">Communications biology</searchLink> [Commun Biol] 2025 Apr 09; Vol. 8 (1), pp. 589. <i>Date of Electronic Publication: </i>2025 Apr 09.
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