Translational genomics of osteoarthritis in 1,962,069 individuals.

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Title: Translational genomics of osteoarthritis in 1,962,069 individuals.
Authors: Hatzikotoulas K; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Southam L; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Stefansdottir L; deCODE Genetics/Amgen, Reykjavik, Iceland., Boer CG; Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands., McDonald ML; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Epidemiology, School of Public Health, UAB, Birmingham, AL, USA.; Department of Genetics, School of Medicine, UAB, Birmingham, AL, USA., Pett JP; Wellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK., Park YC; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Tuerlings M; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Mulders R; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Barysenka A; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Arruda AL; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Tragante V; deCODE Genetics/Amgen, Reykjavik, Iceland., Rocco A; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA., Bittner N; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Chen S; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Horn S; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Srinivasasainagendra V; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.; Department of Biostatistics, School of Public Health, UAB, Birmingham, AL, USA., To K; Wellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Katsoula G; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Kreitmaier P; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Tenghe AMM; Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tübingen, Germany., Gilly A; Regeneron Genetics Center, Tarrytown, NY, USA., Arbeeva L; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Chen LG; Department of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong., de Pins AM; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dochtermann D; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA., Henkel C; Clinical Orthopaedic Research Hvidovre (CORH), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Höijer J; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Ito S; Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan.; Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Lind PA; Psychiatric Genetics, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia., Lukusa-Sawalena B; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA., Minn AKK; Tohoku University Graduate School of Medicine, Sendai, Japan., Mola-Caminal M; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Narita A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Nguyen C; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA., Reimann E; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Silberstein MD; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Skogholt AH; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway., Tiwari HK; Department of Biostatistics, School of Public Health, UAB, Birmingham, AL, USA., Yau MS; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, USA., Yue M; School of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong., Zhao W; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Zhou JJ; Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Alexiadis G; 1st Department of Orthopaedics, KAT General Hospital, Athens, Greece., Banasik K; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK., Cheung JTS; Faculty of Medical Sciences, University College London, London, UK., Dowsett J; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Faquih T; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Fei L; Wellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK., Fenstad AM; The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway., Funayama T; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Gabrielsen ME; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway., Gocho C; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Gromov K; Clinical Orthopaedic Research Hvidovre (CORH), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Hansen T; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet - Glostrup, Glostrup, Denmark., Hudjashov G; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Ingvarsson T; Department of Orthopedic Surgery, Akureyri Hospital, Akureyri, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Johnson JS; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Jonsson H; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali The National University Hospital of Iceland, Reykjavik, Iceland., Kakehi S; Department of Metabolism & Endocrinology, Sportology Center, Juntendo University Graduate School of Medicine, Juntendo University, Tokyo, Japan., Karjalainen J; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Kasbohm E; Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany., Lemmelä S; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Liu X; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Loef M; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Mangino M; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK., McCartney D; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK., Millwood IY; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Richman J; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.; Department of Surgery, School of Medicine, UAB, Birmingham, AL, USA., Roberts MB; Center for Primary Care & Prevention, Brown University, Pawtucket, RI, USA., Ryan KA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Samartzis D; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China.; Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA., Shivakumar M; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Skou ST; Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.; The Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Næstved-Slagelse-Ringsted Hospitals, Slagelse, Denmark., Sugimoto S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Suzuki K; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Takuwa H; Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan., Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Thomas L; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Tomizuka K; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Turman C; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Weiss S; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Wu TT; Department of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong., Zengini E; 4th Psychiatric Department, Dromokaiteio Psychiatric Hospital, Haidari, Athens, Greece., Zhang Y; Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA., Ferreira MAR; Regeneron Genetics Center, Tarrytown, NY, USA., Babis G; 2nd Department of Orthopaedics, National and Kapodistrian University of Athens, Medical School, 'Konstantopouleio' Hospital, Athens, Greece., Baras A; Regeneron Genetics Center, Tarrytown, NY, USA., Barker T; Sports Medicine Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; Intermountain Healthcare, Precision Genomics, Salt Lake City, UT, USA.; Department of Orthopaedics, University of Utah, Salt Lake City, UT, USA., Carey DJ; Department of Genomic Health, Geisinger, Danville, PA, USA., Cheah KSE; School of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Cheung JP; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China., Daly M; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Eaton CB; Center for Primary Care & Prevention, Brown University, Pawtucket, RI, USA.; Department of Family Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA.; Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Furnes ON; The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway., Golightly YM; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; University of Nebraska Medical Center, Omaha, NE, USA., Gudbjartsson DF; deCODE Genetics/Amgen, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Hailer NP; Orthopedics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Hayward C; MRC Human Genetics Unit IGC, University of Edinburgh, Edinburgh, UK., Hochberg MC; Department of Epidemiology and Public Health, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Homuth G; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Huckins LM; Department of Psychiatry, Yale School of Medicine, Yale University, New Haven, CT, USA., Hveem K; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Levanger, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Ikegawa S; Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Ishijima M; Department of Medicine for Orthopaedics and Motor Organ, Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan., Isomura M; Faculty of Human Sciences, Shimane University, Matsue, Japan., Jones M; Regeneron Genetics Center, Tarrytown, NY, USA., Kang JH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kloppenburg M; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Kumahashi N; Department of Orthopedic Surgery, Matsue Red Cross Hospital, Matsue, Japan., Kuwata S; Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan., Lee MTM; Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA., Lee PH; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, USA., Lerner R; Blizard Institute, Queen Mary University of London, London, UK., Li L; Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China., Lietman SA; Musculoskeletal Institute, Geisinger, Danville, PA, USA., Lotta L; Regeneron Genetics Center, Tarrytown, NY, USA., Lupton MK; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; Neurogenetics and Dementia, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Martin NG; Genetic Epidemiology, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., McAlindon TE; Division of Rheumatology, Allergy, & Immunology, Tufts Medical Center, Boston, MA, USA., Medland SE; Psychiatric Genetics, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Psychology, University of Queensland, Brisbane, Queensland, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Michaëlsson K; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Mook-Kanamori DO; Department of Public Health, Leiden University Medical Center, Leiden, The Netherlands., Morris AP; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK., Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan., Nagami F; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Nelson AE; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Palotie A; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Pedersen OB; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital - Køge, Køge, Denmark., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Sakurai-Yageta M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Schmidt CO; Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany., Sham PC; Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong., Singh JA; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.; Department of Epidemiology, School of Public Health, UAB, Birmingham, AL, USA.; Division of Rheumatology and Clinical Immunology, Department of Medicine at the School of Medicine, UAB, Birmingham, AL, USA.; Medicine Service, Michale E. DeBakey VA Medical Center, Houston, TX, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Smelser DT; Department of Genomic Health, Geisinger, Danville, PA, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Song YQ; School of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Tamiya G; Tohoku University Graduate School of Medicine, Sendai, Japan.; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Statistical Genetics Team, Center for Advanced Intelligence Project, RIKEN, Tokyo, Japan., Tamura Y; Department of Metabolism & Endocrinology, Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan., Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.; The Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan., Thorleifsson G; deCODE Genetics/Amgen, Reykjavik, Iceland., Troelsen A; Clinical Academic Group: Research OsteoArthritis Denmark (CAG ROAD), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Tsezou A; Laboratory of Cytogenetics and Molecular Genetics, Faculty of Medicine, University of Thessaly, Larissa, Greece., Uchio Y; Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan., Uitterlinden AG; Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands., Ullum H; Statens Serum Institute, Copenhagen, Denmark., Valdes AM; Faculty of Medicine & Health Sciences, School of Medicine, University of Nottingham, Nottingham, UK., van Heel DA; Blizard Institute, Queen Mary University of London, London, UK., Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Wilkinson JM; School of Medicine and Population Health, The University of Sheffield, Sheffield, UK., Winsvold BS; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway., Yamamoto M; Tohoku University Graduate School of Medicine, Sendai, Japan.; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Zwart JA; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Stefansson K; deCODE Genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Meulenbelt I; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Teichmann SA; Department of Medicine & Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., van Meurs JBJ; Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands., Styrkarsdottir U; deCODE Genetics/Amgen, Reykjavik, Iceland., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. eleftheria.zeggini@helmholtz-munich.de.; TUM School of Medicine and Health, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany. eleftheria.zeggini@helmholtz-munich.de.
Corporate Authors: arcOGEN Consortium, ARGO Consortium, DBDS Genomic Consortium, Estonian Biobank Research Team, FinnGen, Genes & Health Research Team, HUNT All-In Pain, Million Veteran Program, Regeneron Genetics Center
Source: Nature [Nature] 2025 May; Vol. 641 (8065), pp. 1217-1224. Date of Electronic Publication: 2025 Apr 09.
Publication Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-025-08771-z