Translational genomics of osteoarthritis in 1,962,069 individuals.

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Title: Translational genomics of osteoarthritis in 1,962,069 individuals.
Authors: Hatzikotoulas K; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Southam L; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Stefansdottir L; deCODE Genetics/Amgen, Reykjavik, Iceland., Boer CG; Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands., McDonald ML; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.; Department of Epidemiology, School of Public Health, UAB, Birmingham, AL, USA.; Department of Genetics, School of Medicine, UAB, Birmingham, AL, USA., Pett JP; Wellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK., Park YC; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Tuerlings M; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Mulders R; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Barysenka A; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Arruda AL; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Tragante V; deCODE Genetics/Amgen, Reykjavik, Iceland., Rocco A; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA., Bittner N; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Chen S; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Horn S; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Srinivasasainagendra V; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.; Department of Biostatistics, School of Public Health, UAB, Birmingham, AL, USA., To K; Wellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Katsoula G; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Kreitmaier P; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Tenghe AMM; Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tübingen, Germany., Gilly A; Regeneron Genetics Center, Tarrytown, NY, USA., Arbeeva L; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Chen LG; Department of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong., de Pins AM; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dochtermann D; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA., Henkel C; Clinical Orthopaedic Research Hvidovre (CORH), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Höijer J; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Ito S; Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan.; Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Lind PA; Psychiatric Genetics, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia., Lukusa-Sawalena B; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA., Minn AKK; Tohoku University Graduate School of Medicine, Sendai, Japan., Mola-Caminal M; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Narita A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Nguyen C; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA., Reimann E; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Silberstein MD; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Skogholt AH; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway., Tiwari HK; Department of Biostatistics, School of Public Health, UAB, Birmingham, AL, USA., Yau MS; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, USA., Yue M; School of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong., Zhao W; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Zhou JJ; Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, USA., Alexiadis G; 1st Department of Orthopaedics, KAT General Hospital, Athens, Greece., Banasik K; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK., Cheung JTS; Faculty of Medical Sciences, University College London, London, UK., Dowsett J; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Faquih T; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Fei L; Wellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK., Fenstad AM; The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway., Funayama T; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Gabrielsen ME; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway., Gocho C; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Gromov K; Clinical Orthopaedic Research Hvidovre (CORH), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Hansen T; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet - Glostrup, Glostrup, Denmark., Hudjashov G; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Ingvarsson T; Department of Orthopedic Surgery, Akureyri Hospital, Akureyri, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Johnson JS; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Jonsson H; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali The National University Hospital of Iceland, Reykjavik, Iceland., Kakehi S; Department of Metabolism & Endocrinology, Sportology Center, Juntendo University Graduate School of Medicine, Juntendo University, Tokyo, Japan., Karjalainen J; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Kasbohm E; Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany., Lemmelä S; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Liu X; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Loef M; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Mangino M; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK., McCartney D; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK., Millwood IY; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Richman J; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.; Department of Surgery, School of Medicine, UAB, Birmingham, AL, USA., Roberts MB; Center for Primary Care & Prevention, Brown University, Pawtucket, RI, USA., Ryan KA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Samartzis D; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China.; Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA., Shivakumar M; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Skou ST; Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.; The Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Næstved-Slagelse-Ringsted Hospitals, Slagelse, Denmark., Sugimoto S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Suzuki K; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Takuwa H; Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan., Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Thomas L; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Tomizuka K; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Turman C; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Weiss S; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Wu TT; Department of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong., Zengini E; 4th Psychiatric Department, Dromokaiteio Psychiatric Hospital, Haidari, Athens, Greece., Zhang Y; Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA., Ferreira MAR; Regeneron Genetics Center, Tarrytown, NY, USA., Babis G; 2nd Department of Orthopaedics, National and Kapodistrian University of Athens, Medical School, 'Konstantopouleio' Hospital, Athens, Greece., Baras A; Regeneron Genetics Center, Tarrytown, NY, USA., Barker T; Sports Medicine Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; Intermountain Healthcare, Precision Genomics, Salt Lake City, UT, USA.; Department of Orthopaedics, University of Utah, Salt Lake City, UT, USA., Carey DJ; Department of Genomic Health, Geisinger, Danville, PA, USA., Cheah KSE; School of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Cheung JP; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China., Daly M; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Eaton CB; Center for Primary Care & Prevention, Brown University, Pawtucket, RI, USA.; Department of Family Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA.; Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Furnes ON; The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway., Golightly YM; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; University of Nebraska Medical Center, Omaha, NE, USA., Gudbjartsson DF; deCODE Genetics/Amgen, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Hailer NP; Orthopedics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Hayward C; MRC Human Genetics Unit IGC, University of Edinburgh, Edinburgh, UK., Hochberg MC; Department of Epidemiology and Public Health, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Homuth G; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Huckins LM; Department of Psychiatry, Yale School of Medicine, Yale University, New Haven, CT, USA., Hveem K; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Levanger, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Ikegawa S; Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Ishijima M; Department of Medicine for Orthopaedics and Motor Organ, Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan., Isomura M; Faculty of Human Sciences, Shimane University, Matsue, Japan., Jones M; Regeneron Genetics Center, Tarrytown, NY, USA., Kang JH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kloppenburg M; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Kumahashi N; Department of Orthopedic Surgery, Matsue Red Cross Hospital, Matsue, Japan., Kuwata S; Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan., Lee MTM; Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA., Lee PH; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, USA., Lerner R; Blizard Institute, Queen Mary University of London, London, UK., Li L; Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China., Lietman SA; Musculoskeletal Institute, Geisinger, Danville, PA, USA., Lotta L; Regeneron Genetics Center, Tarrytown, NY, USA., Lupton MK; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; Neurogenetics and Dementia, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Martin NG; Genetic Epidemiology, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., McAlindon TE; Division of Rheumatology, Allergy, & Immunology, Tufts Medical Center, Boston, MA, USA., Medland SE; Psychiatric Genetics, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Psychology, University of Queensland, Brisbane, Queensland, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Michaëlsson K; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Mook-Kanamori DO; Department of Public Health, Leiden University Medical Center, Leiden, The Netherlands., Morris AP; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK., Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan., Nagami F; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Nelson AE; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Palotie A; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Pedersen OB; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital - Køge, Køge, Denmark., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Sakurai-Yageta M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Schmidt CO; Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany., Sham PC; Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong., Singh JA; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.; Department of Epidemiology, School of Public Health, UAB, Birmingham, AL, USA.; Division of Rheumatology and Clinical Immunology, Department of Medicine at the School of Medicine, UAB, Birmingham, AL, USA.; Medicine Service, Michale E. DeBakey VA Medical Center, Houston, TX, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Smelser DT; Department of Genomic Health, Geisinger, Danville, PA, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Song YQ; School of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Tamiya G; Tohoku University Graduate School of Medicine, Sendai, Japan.; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Statistical Genetics Team, Center for Advanced Intelligence Project, RIKEN, Tokyo, Japan., Tamura Y; Department of Metabolism & Endocrinology, Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan., Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.; The Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan., Thorleifsson G; deCODE Genetics/Amgen, Reykjavik, Iceland., Troelsen A; Clinical Academic Group: Research OsteoArthritis Denmark (CAG ROAD), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Tsezou A; Laboratory of Cytogenetics and Molecular Genetics, Faculty of Medicine, University of Thessaly, Larissa, Greece., Uchio Y; Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan., Uitterlinden AG; Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands., Ullum H; Statens Serum Institute, Copenhagen, Denmark., Valdes AM; Faculty of Medicine & Health Sciences, School of Medicine, University of Nottingham, Nottingham, UK., van Heel DA; Blizard Institute, Queen Mary University of London, London, UK., Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Wilkinson JM; School of Medicine and Population Health, The University of Sheffield, Sheffield, UK., Winsvold BS; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway., Yamamoto M; Tohoku University Graduate School of Medicine, Sendai, Japan.; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Zwart JA; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Stefansson K; deCODE Genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Meulenbelt I; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Teichmann SA; Department of Medicine & Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., van Meurs JBJ; Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands., Styrkarsdottir U; deCODE Genetics/Amgen, Reykjavik, Iceland., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. eleftheria.zeggini@helmholtz-munich.de.; TUM School of Medicine and Health, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany. eleftheria.zeggini@helmholtz-munich.de.
Corporate Authors: arcOGEN Consortium, ARGO Consortium, DBDS Genomic Consortium, Estonian Biobank Research Team, FinnGen, Genes & Health Research Team, HUNT All-In Pain, Million Veteran Program, Regeneron Genetics Center
Source: Nature [Nature] 2025 May; Vol. 641 (8065), pp. 1217-1224. Date of Electronic Publication: 2025 Apr 09.
Publication Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Translational genomics of osteoarthritis in 1,962,069 individuals.
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Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Horn+S%22">Horn S</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Srinivasasainagendra+V%22">Srinivasasainagendra V</searchLink>; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.; Department of Biostatistics, School of Public Health, UAB, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22To+K%22">To K</searchLink>; Wellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Katsoula+G%22">Katsoula G</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kreitmaier+P%22">Kreitmaier P</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Tenghe+AMM%22">Tenghe AMM</searchLink>; Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Gilly+A%22">Gilly A</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Arbeeva+L%22">Arbeeva L</searchLink>; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Chen+LG%22">Chen LG</searchLink>; Department of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22de+Pins+AM%22">de Pins AM</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dochtermann+D%22">Dochtermann D</searchLink>; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Henkel+C%22">Henkel C</searchLink>; Clinical Orthopaedic Research Hvidovre (CORH), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Höijer+J%22">Höijer J</searchLink>; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Ito+S%22">Ito S</searchLink>; Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan.; Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Lind+PA%22">Lind PA</searchLink>; Psychiatric Genetics, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Lukusa-Sawalena+B%22">Lukusa-Sawalena B</searchLink>; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Minn+AKK%22">Minn AKK</searchLink>; Tohoku University Graduate School of Medicine, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Mola-Caminal+M%22">Mola-Caminal M</searchLink>; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Narita+A%22">Narita A</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Nguyen+C%22">Nguyen C</searchLink>; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Reimann+E%22">Reimann E</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Silberstein+MD%22">Silberstein MD</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Skogholt+AH%22">Skogholt AH</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Tiwari+HK%22">Tiwari HK</searchLink>; Department of Biostatistics, School of Public Health, UAB, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Yau+MS%22">Yau MS</searchLink>; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yue+M%22">Yue M</searchLink>; School of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+JJ%22">Zhou JJ</searchLink>; Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Alexiadis+G%22">Alexiadis G</searchLink>; 1st Department of Orthopaedics, KAT General Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Banasik+K%22">Banasik K</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Brunak+S%22">Brunak S</searchLink>; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Campbell+A%22">Campbell A</searchLink>; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Cheung+JTS%22">Cheung JTS</searchLink>; Faculty of Medical Sciences, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Dowsett+J%22">Dowsett J</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Faquih+T%22">Faquih T</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Faul+JD%22">Faul JD</searchLink>; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Fei+L%22">Fei L</searchLink>; Wellcome Sanger Institute, Cellular Genetics Programme, Wellcome Genome Campus, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Fenstad+AM%22">Fenstad AM</searchLink>; The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Funayama+T%22">Funayama T</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Gabrielsen+ME%22">Gabrielsen ME</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Gocho+C%22">Gocho C</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Gromov+K%22">Gromov K</searchLink>; Clinical Orthopaedic Research Hvidovre (CORH), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Hansen+T%22">Hansen T</searchLink>; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet - Glostrup, Glostrup, Denmark.<br /><searchLink fieldCode="AU" term="%22Hudjashov+G%22">Hudjashov G</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Ingvarsson+T%22">Ingvarsson T</searchLink>; Department of Orthopedic Surgery, Akureyri Hospital, Akureyri, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Johnson+JS%22">Johnson JS</searchLink>; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Jonsson+H%22">Jonsson H</searchLink>; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Medicine, Landspitali The National University Hospital of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Kakehi+S%22">Kakehi S</searchLink>; Department of Metabolism & Endocrinology, Sportology Center, Juntendo University Graduate School of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Karjalainen+J%22">Karjalainen J</searchLink>; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kasbohm+E%22">Kasbohm E</searchLink>; Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Lemmelä+S%22">Lemmelä S</searchLink>; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Finnish Institute for Health and Welfare (THL), Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Lin+K%22">Lin K</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Loef+M%22">Loef M</searchLink>; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mangino+M%22">Mangino M</searchLink>; Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.<br /><searchLink fieldCode="AU" term="%22McCartney+D%22">McCartney D</searchLink>; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Millwood+IY%22">Millwood IY</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Richman+J%22">Richman J</searchLink>; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.; Department of Surgery, School of Medicine, UAB, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+MB%22">Roberts MB</searchLink>; Center for Primary Care & Prevention, Brown University, Pawtucket, RI, USA.<br /><searchLink fieldCode="AU" term="%22Ryan+KA%22">Ryan KA</searchLink>; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Samartzis+D%22">Samartzis D</searchLink>; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China.; Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Shivakumar+M%22">Shivakumar M</searchLink>; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Skou+ST%22">Skou ST</searchLink>; Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.; The Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Næstved-Slagelse-Ringsted Hospitals, Slagelse, Denmark.<br /><searchLink fieldCode="AU" term="%22Sugimoto+S%22">Sugimoto S</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+K%22">Suzuki K</searchLink>; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Takuwa+H%22">Takuwa H</searchLink>; Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Teder-Laving+M%22">Teder-Laving M</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Thomas+L%22">Thomas L</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Tomizuka+K%22">Tomizuka K</searchLink>; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Turman+C%22">Turman C</searchLink>; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Weiss+S%22">Weiss S</searchLink>; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Wu+TT%22">Wu TT</searchLink>; Department of Psychiatry, The University of Hong Kong, Pok Fu Lam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Zengini+E%22">Zengini E</searchLink>; 4th Psychiatric Department, Dromokaiteio Psychiatric Hospital, Haidari, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ferreira+MAR%22">Ferreira MAR</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Babis+G%22">Babis G</searchLink>; 2nd Department of Orthopaedics, National and Kapodistrian University of Athens, Medical School, 'Konstantopouleio' Hospital, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Baras+A%22">Baras A</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Barker+T%22">Barker T</searchLink>; Sports Medicine Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; Intermountain Healthcare, Precision Genomics, Salt Lake City, UT, USA.; Department of Orthopaedics, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Carey+DJ%22">Carey DJ</searchLink>; Department of Genomic Health, Geisinger, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cheah+KSE%22">Cheah KSE</searchLink>; School of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cheung+JP%22">Cheung JP</searchLink>; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Daly+M%22">Daly M</searchLink>; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22de+Mutsert+R%22">de Mutsert R</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Eaton+CB%22">Eaton CB</searchLink>; Center for Primary Care & Prevention, Brown University, Pawtucket, RI, USA.; Department of Family Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA.; Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.<br /><searchLink fieldCode="AU" term="%22Erikstrup+C%22">Erikstrup C</searchLink>; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Furnes+ON%22">Furnes ON</searchLink>; The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Golightly+YM%22">Golightly YM</searchLink>; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; University of Nebraska Medical Center, Omaha, NE, USA.<br /><searchLink fieldCode="AU" term="%22Gudbjartsson+DF%22">Gudbjartsson DF</searchLink>; deCODE Genetics/Amgen, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Hailer+NP%22">Hailer NP</searchLink>; Orthopedics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Hayward+C%22">Hayward C</searchLink>; MRC Human Genetics Unit IGC, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Hochberg+MC%22">Hochberg MC</searchLink>; Department of Epidemiology and Public Health, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Homuth+G%22">Homuth G</searchLink>; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Huckins+LM%22">Huckins LM</searchLink>; Department of Psychiatry, Yale School of Medicine, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Hveem+K%22">Hveem K</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Levanger, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.<br /><searchLink fieldCode="AU" term="%22Ikegawa+S%22">Ikegawa S</searchLink>; Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Ishijima+M%22">Ishijima M</searchLink>; Department of Medicine for Orthopaedics and Motor Organ, Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Isomura+M%22">Isomura M</searchLink>; Faculty of Human Sciences, Shimane University, Matsue, Japan.<br /><searchLink fieldCode="AU" term="%22Jones+M%22">Jones M</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kang+JH%22">Kang JH</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kardia+SLR%22">Kardia SLR</searchLink>; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Kloppenburg+M%22">Kloppenburg M</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kraft+P%22">Kraft P</searchLink>; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kumahashi+N%22">Kumahashi N</searchLink>; Department of Orthopedic Surgery, Matsue Red Cross Hospital, Matsue, Japan.<br /><searchLink fieldCode="AU" term="%22Kuwata+S%22">Kuwata S</searchLink>; Department of Orthopedic Surgery, Shimane University Faculty of Medicine, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Lee+MTM%22">Lee MTM</searchLink>; Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+PH%22">Lee PH</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Lerner+R%22">Lerner R</searchLink>; Blizard Institute, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lietman+SA%22">Lietman SA</searchLink>; Musculoskeletal Institute, Geisinger, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lotta+L%22">Lotta L</searchLink>; Regeneron Genetics Center, Tarrytown, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lupton+MK%22">Lupton MK</searchLink>; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; Neurogenetics and Dementia, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Mägi+R%22">Mägi R</searchLink>; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Martin+NG%22">Martin NG</searchLink>; Genetic Epidemiology, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22McAlindon+TE%22">McAlindon TE</searchLink>; Division of Rheumatology, Allergy, & Immunology, Tufts Medical Center, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Medland+SE%22">Medland SE</searchLink>; Psychiatric Genetics, Brain and Mental Health Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Psychology, University of Queensland, Brisbane, Queensland, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Michaëlsson+K%22">Michaëlsson K</searchLink>; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Mitchell+BD%22">Mitchell BD</searchLink>; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mook-Kanamori+DO%22">Mook-Kanamori DO</searchLink>; Department of Public Health, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Morris+AP%22">Morris AP</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Nabika+T%22">Nabika T</searchLink>; Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Nagami+F%22">Nagami F</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Nelson+AE%22">Nelson AE</searchLink>; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ostrowski+SR%22">Ostrowski SR</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Palotie+A%22">Palotie A</searchLink>; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pedersen+OB%22">Pedersen OB</searchLink>; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital - Køge, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Rosendaal+FR%22">Rosendaal FR</searchLink>; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sakurai-Yageta+M%22">Sakurai-Yageta M</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Schmidt+CO%22">Schmidt CO</searchLink>; Institute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Sham+PC%22">Sham PC</searchLink>; Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Singh+JA%22">Singh JA</searchLink>; Birmingham Veterans Affairs Healthcare System (BVAHS), Birmingham, AL, USA.; Department of Epidemiology, School of Public Health, UAB, Birmingham, AL, USA.; Division of Rheumatology and Clinical Immunology, Department of Medicine at the School of Medicine, UAB, Birmingham, AL, USA.; Medicine Service, Michale E. DeBakey VA Medical Center, Houston, TX, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Smelser+DT%22">Smelser DT</searchLink>; Department of Genomic Health, Geisinger, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+JA%22">Smith JA</searchLink>; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Song+YQ%22">Song YQ</searchLink>; School of Biomedical Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Sørensen+E%22">Sørensen E</searchLink>; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Tamiya+G%22">Tamiya G</searchLink>; Tohoku University Graduate School of Medicine, Sendai, Japan.; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Statistical Genetics Team, Center for Advanced Intelligence Project, RIKEN, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tamura+Y%22">Tamura Y</searchLink>; Department of Metabolism & Endocrinology, Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Terao+C%22">Terao C</searchLink>; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.; The Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Thorleifsson+G%22">Thorleifsson G</searchLink>; deCODE Genetics/Amgen, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Troelsen+A%22">Troelsen A</searchLink>; Clinical Academic Group: Research OsteoArthritis Denmark (CAG ROAD), Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Tsezou+A%22">Tsezou A</searchLink>; 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Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Wilkinson+JM%22">Wilkinson JM</searchLink>; School of Medicine and Population Health, The University of Sheffield, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Winsvold+BS%22">Winsvold BS</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Yamamoto+M%22">Yamamoto M</searchLink>; Tohoku University Graduate School of Medicine, Sendai, Japan.; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Zwart+JA%22">Zwart JA</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Stefansson+K%22">Stefansson K</searchLink>; deCODE Genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Meulenbelt+I%22">Meulenbelt I</searchLink>; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Teichmann+SA%22">Teichmann SA</searchLink>; Department of Medicine & Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22van+Meurs+JBJ%22">van Meurs JBJ</searchLink>; Department of Internal Medicine, Erasmus MC Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Styrkarsdottir+U%22">Styrkarsdottir U</searchLink>; deCODE Genetics/Amgen, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Zeggini+E%22">Zeggini E</searchLink>; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. eleftheria.zeggini@helmholtz-munich.de.; TUM School of Medicine and Health, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany. eleftheria.zeggini@helmholtz-munich.de.
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  Data: <searchLink fieldCode="CA" term="%22arcOGEN+Consortium%22">arcOGEN Consortium</searchLink><br /><searchLink fieldCode="CA" term="%22ARGO+Consortium%22">ARGO Consortium</searchLink><br /><searchLink fieldCode="CA" term="%22DBDS+Genomic+Consortium%22">DBDS Genomic Consortium</searchLink><br /><searchLink fieldCode="CA" term="%22Estonian+Biobank+Research+Team%22">Estonian Biobank Research Team</searchLink><br /><searchLink fieldCode="CA" term="%22FinnGen%22">FinnGen</searchLink><br /><searchLink fieldCode="CA" term="%22Genes+%26+Health+Research+Team%22">Genes & Health Research Team</searchLink><br /><searchLink fieldCode="CA" term="%22HUNT+All-In+Pain%22">HUNT All-In Pain</searchLink><br /><searchLink fieldCode="CA" term="%22Million+Veteran+Program%22">Million Veteran Program</searchLink><br /><searchLink fieldCode="CA" term="%22Regeneron+Genetics+Center%22">Regeneron Genetics Center</searchLink>
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2025 May; Vol. 641 (8065), pp. 1217-1224. <i>Date of Electronic Publication: </i>2025 Apr 09.
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  Data: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0410462 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4687 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200280836%22">00280836 </searchLink><i>NLM ISO Abbreviation: </i>Nature <i>Subsets: </i>MEDLINE
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            – D: 01
              M: 05
              Text: 2025 May
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
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              Value: 641
            – Type: issue
              Value: 8065
          Titles:
            – TitleFull: Nature
              Type: main
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