Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair.
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| Title: | Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair. |
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| Authors: | Trasviña-Arenas CH; Department of Chemistry, University of California, Davis, CA, USA.; Research Center on Aging, Center for Research and Advanced Studies (CINVESTAV), Mexico City, Mexico., Dissanayake UC; Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, TX, USA., Tamayo N; Department of Chemistry, University of California, Davis, CA, USA.; Chemistry and Chemical Biology Graduate Program, University of California, Davis, CA, USA., Hashemian M; Department of Chemistry, University of California, Davis, CA, USA.; Chemistry and Chemical Biology Graduate Program, University of California, Davis, CA, USA., Lin WJ; Department of Chemistry, University of California, Davis, CA, USA.; Chemistry and Chemical Biology Graduate Program, University of California, Davis, CA, USA., Demir M; Department of Chemistry, University of California, Davis, CA, USA.; Chemistry and Chemical Biology Graduate Program, University of California, Davis, CA, USA., Hoyos-Gonzalez N; Department of Chemistry, University of California, Davis, CA, USA., Fisher AJ; Department of Chemistry, University of California, Davis, CA, USA.; Chemistry and Chemical Biology Graduate Program, University of California, Davis, CA, USA.; Department of Molecular and Cellular Biology, University of California, Davis, CA, USA., Cisneros GA; Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, TX, USA. andres@utdallas.edu.; Department of Physics, University of Texas at Dallas, Richardson, TX, USA. andres@utdallas.edu., Horvath MP; School of Biological Sciences, University of Utah, Salt Lake City, UT, USA. martin.horvath@utah.edu., David SS; Department of Chemistry, University of California, Davis, CA, USA. ssdavid@ucdavis.edu.; Chemistry and Chemical Biology Graduate Program, University of California, Davis, CA, USA. ssdavid@ucdavis.edu. |
| Source: | Nature communications [Nat Commun] 2025 Apr 16; Vol. 16 (1), pp. 3596. Date of Electronic Publication: 2025 Apr 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-58361-w |
