PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration.

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Title: PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration.
Authors: Goto A; Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan., Komura S; Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan. komura.shingo.m7@f.gifu-u.ac.jp., Kato K; Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan., Maki R; Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan., Hirakawa A; Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan., Aoki H; Department of Stem Cell and Regenerative Medicine, Gifu University Graduate School of Medicine, Gifu, Japan., Tomita H; Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan.; Center for One Medicine Innovative Translational Research (COMIT), Gifu University, Gifu, Japan., Taguchi J; Core Laboratory for Developing Advanced Animal Models, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Ozawa M; Core Laboratory for Developing Advanced Animal Models, Institute of Medical Science, University of Tokyo, Tokyo, Japan., Matsushima T; Department of Systems BioMedicine, Institute of Science Tokyo, Tokyo, Japan., Kishida A; Department of Material-Based Medical Engineering, Laboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo, Tokyo, Japan., Kimura T; Materials-based Medical Engineering Laboratory, Department of Biomedical Engineering, Faculty of Life Science, Toyo University, Tokyo, Japan., Asahara H; Department of Systems BioMedicine, Institute of Science Tokyo, Tokyo, Japan., Imai Y; Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University, Toon, Ehime, Japan., Yamada Y; Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Akiyama H; Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan.; Center for One Medicine Innovative Translational Research (COMIT), Gifu University, Gifu, Japan.
Source: Nature communications [Nat Commun] 2025 Apr 20; Vol. 16 (1), pp. 3734. Date of Electronic Publication: 2025 Apr 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-59010-y