Immunogenicity of MVA-BN vaccine deployed as mpox prophylaxis: a prospective, single-centre, cohort study and analysis of transcriptomic predictors of response.

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Title: Immunogenicity of MVA-BN vaccine deployed as mpox prophylaxis: a prospective, single-centre, cohort study and analysis of transcriptomic predictors of response.
Authors: Drennan PG; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Electronic address: philip.drennan@ndorms.ox.ac.uk., Provine NM; Pandemic Sciences Institute, University of Oxford, Oxford, UK; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Harris SA; Jenner Institute, University of Oxford, Oxford, UK., Otter A; Emerging Pathogen Serology Group, UK Health Security Agency, Porton Down, UK., Hollett K; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Cooper C; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., De Maeyer RPH; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Nassanga B; Jenner Institute, University of Oxford, Oxford, UK., Ateere A; Jenner Institute, University of Oxford, Oxford, UK., Pudjohartono MF; Pandemic Sciences Institute, University of Oxford, Oxford, UK., Peng Y; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK; MRC Translational Immune Discovery Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Chen JL; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK; MRC Translational Immune Discovery Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Jones S; Emerging Pathogen Serology Group, UK Health Security Agency, Porton Down, UK., Fadzillah NHM; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Grifoni A; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Sette A; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Satti I; Jenner Institute, University of Oxford, Oxford, UK., Murray SM; Emerging Pathogen Serology Group, UK Health Security Agency, Porton Down, UK., Rowe C; Emerging Pathogen Serology Group, UK Health Security Agency, Porton Down, UK., Mandal S; UK Health Security Agency, Colindale, UK., Hallis B; Emerging Pathogen Serology Group, UK Health Security Agency, Porton Down, UK., Klenerman P; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Dong T; Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK; MRC Translational Immune Discovery Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Richards D; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Fullerton J; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., McShane H; Jenner Institute, University of Oxford, Oxford, UK., Coles M; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Source: The Lancet. Microbe [Lancet Microbe] 2025 Jun; Vol. 6 (6), pp. 101045. Date of Electronic Publication: 2025 Apr 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2666-5247
DOI:10.1016/j.lanmic.2024.101045