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Methionine sulfoxide reductase A deficiency aggravated ferroptosis in LPS-induced acute kidney injury by inhibiting the AMPK/NRF2 axis and activating the CaMKII/HIF-1α pathway.

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Title: Methionine sulfoxide reductase A deficiency aggravated ferroptosis in LPS-induced acute kidney injury by inhibiting the AMPK/NRF2 axis and activating the CaMKII/HIF-1α pathway.
Authors: Yang L; Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China., Xiao JJ; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China; Department of Cardiology, Zhongnan Hospital of Wuhan University, Institute of Myocardial Injury and Repair, Wuhan University, Wuhan, 430071, China., Zhang L; Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China., Lu Q; Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China., Hu BB; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China., Liu Y; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China., Pu JX; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China., Hu JW; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China., Yu H; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China. Electronic address: yu.hong@whu.edu.cn., Wu X; Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: wuxiaoyan2k6@whu.edu.cn., Zhang BF; Department of Biochemistry and Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University TaiKang Medical School (School of Basic Medical Sciences), Wuhan, China. Electronic address: zbfwq@whu.edu.cn.
Source: Free radical biology & medicine [Free Radic Biol Med] 2025 Jul; Vol. 234, pp. 248-263. Date of Electronic Publication: 2025 Apr 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1873-4596
DOI:10.1016/j.freeradbiomed.2025.04.040