Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome.

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Title: Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome.
Authors: Hile SE; Department of Pathology, The Jake Gittlen Laboratories for Cancer Research, Penn State University College of Medicine, Hershey, PA 17033, United States., Weissensteiner MH; Department of Biology, Penn State University Eberly College of Science, University Park, PA 16802, United States., Pytko KG; Department of Chemistry, Penn State University Eberly College of Science, University Park, PA 16802, United States., Dahl J; National Institute of Environmental Health Sciences, Z01 ES065070, Durham, NC 27709, United States., Kejnovsky E; Department of Plant Developmental Genetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, 61265, Czech Republic., Kejnovská I; Department of Biophysics of Nucleic Acids, Institute of Biophysics of the Czech Academy of Sciences, Brno, 61265, Czech Republic., Hedglin M; Department of Chemistry, Penn State University Eberly College of Science, University Park, PA 16802, United States., Georgakopoulos-Soares I; Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey, PA, 17033, United States., Makova KD; Department of Biology, Penn State University Eberly College of Science, University Park, PA 16802, United States., Eckert KA; Department of Pathology, The Jake Gittlen Laboratories for Cancer Research, Penn State University College of Medicine, Hershey, PA 17033, United States.
Source: Nucleic acids research [Nucleic Acids Res] 2025 Apr 22; Vol. 53 (8).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1362-4962
DOI:10.1093/nar/gkaf352