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Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome.

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Title: Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome.
Authors: Hile SE; Department of Pathology, The Jake Gittlen Laboratories for Cancer Research, Penn State University College of Medicine, Hershey, PA 17033, United States., Weissensteiner MH; Department of Biology, Penn State University Eberly College of Science, University Park, PA 16802, United States., Pytko KG; Department of Chemistry, Penn State University Eberly College of Science, University Park, PA 16802, United States., Dahl J; National Institute of Environmental Health Sciences, Z01 ES065070, Durham, NC 27709, United States., Kejnovsky E; Department of Plant Developmental Genetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, 61265, Czech Republic., Kejnovská I; Department of Biophysics of Nucleic Acids, Institute of Biophysics of the Czech Academy of Sciences, Brno, 61265, Czech Republic., Hedglin M; Department of Chemistry, Penn State University Eberly College of Science, University Park, PA 16802, United States., Georgakopoulos-Soares I; Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey, PA, 17033, United States., Makova KD; Department of Biology, Penn State University Eberly College of Science, University Park, PA 16802, United States., Eckert KA; Department of Pathology, The Jake Gittlen Laboratories for Cancer Research, Penn State University College of Medicine, Hershey, PA 17033, United States.
Source: Nucleic acids research [Nucleic Acids Res] 2025 Apr 22; Vol. 53 (8).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome.
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  Data: <searchLink fieldCode="AU" term="%22Hile+SE%22">Hile SE</searchLink>; Department of Pathology, The Jake Gittlen Laboratories for Cancer Research, Penn State University College of Medicine, Hershey, PA 17033, United States.<br /><searchLink fieldCode="AU" term="%22Weissensteiner+MH%22">Weissensteiner MH</searchLink>; Department of Biology, Penn State University Eberly College of Science, University Park, PA 16802, United States.<br /><searchLink fieldCode="AU" term="%22Pytko+KG%22">Pytko KG</searchLink>; Department of Chemistry, Penn State University Eberly College of Science, University Park, PA 16802, United States.<br /><searchLink fieldCode="AU" term="%22Dahl+J%22">Dahl J</searchLink>; National Institute of Environmental Health Sciences, Z01 ES065070, Durham, NC 27709, United States.<br /><searchLink fieldCode="AU" term="%22Kejnovsky+E%22">Kejnovsky E</searchLink>; Department of Plant Developmental Genetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, 61265, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kejnovská+I%22">Kejnovská I</searchLink>; Department of Biophysics of Nucleic Acids, Institute of Biophysics of the Czech Academy of Sciences, Brno, 61265, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Hedglin+M%22">Hedglin M</searchLink>; Department of Chemistry, Penn State University Eberly College of Science, University Park, PA 16802, United States.<br /><searchLink fieldCode="AU" term="%22Georgakopoulos-Soares+I%22">Georgakopoulos-Soares I</searchLink>; Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey, PA, 17033, United States.<br /><searchLink fieldCode="AU" term="%22Makova+KD%22">Makova KD</searchLink>; Department of Biology, Penn State University Eberly College of Science, University Park, PA 16802, United States.<br /><searchLink fieldCode="AU" term="%22Eckert+KA%22">Eckert KA</searchLink>; Department of Pathology, The Jake Gittlen Laboratories for Cancer Research, Penn State University College of Medicine, Hershey, PA 17033, United States.
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  Data: <searchLink fieldCode="JN" term="%220411011%22">Nucleic acids research</searchLink> [Nucleic Acids Res] 2025 Apr 22; Vol. 53 (8).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0411011 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1362-4962 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203051048%22">03051048 </searchLink><i>NLM ISO Abbreviation: </i>Nucleic Acids Res <i>Subsets: </i>MEDLINE
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        Value: 10.1093/nar/gkaf352
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        Text: English
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              Text: 2025 Apr 22
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