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Synthesis of 5,9- and 5,8-Diaminoalkoxy Substituted Benzophenanthridinone Analogues as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors and Their Radiosensitizing Activity.

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Title: Synthesis of 5,9- and 5,8-Diaminoalkoxy Substituted Benzophenanthridinone Analogues as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors and Their Radiosensitizing Activity.
Authors: Hu DX; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; School of Pharmacy, Chengdu Medical College, Chengdu 610500, China., Qin C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Guo LS; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Liu WY; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Liang ZQ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Cao Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Yao CS; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Wei Y; Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China., Yue X; The First Affiliated Hospital, Jinan University, Guangzhou 510630, China., Mahmud MRA; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, United States., Agama K; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, United States., Wang H; Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China., Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, United States., An LK; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou 510006, China.
Source: Journal of medicinal chemistry [J Med Chem] 2025 May 08; Vol. 68 (9), pp. 9323-9340. Date of Electronic Publication: 2025 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.4c02951