Synthesis of 5,9- and 5,8-Diaminoalkoxy Substituted Benzophenanthridinone Analogues as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors and Their Radiosensitizing Activity.
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| Title: | Synthesis of 5,9- and 5,8-Diaminoalkoxy Substituted Benzophenanthridinone Analogues as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors and Their Radiosensitizing Activity. |
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| Authors: | Hu DX; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; School of Pharmacy, Chengdu Medical College, Chengdu 610500, China., Qin C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Guo LS; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Liu WY; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Liang ZQ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Cao Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Yao CS; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China., Wei Y; Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China., Yue X; The First Affiliated Hospital, Jinan University, Guangzhou 510630, China., Mahmud MRA; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, United States., Agama K; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, United States., Wang H; Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China., Pommier Y; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, United States., An LK; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou 510006, China. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2025 May 08; Vol. 68 (9), pp. 9323-9340. Date of Electronic Publication: 2025 Apr 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40298128 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Synthesis of 5,9- and 5,8-Diaminoalkoxy Substituted Benzophenanthridinone Analogues as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors and Their Radiosensitizing Activity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Hu+DX%22">Hu DX</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; School of Pharmacy, Chengdu Medical College, Chengdu 610500, China.<br /><searchLink fieldCode="AU" term="%22Qin+C%22">Qin C</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.<br /><searchLink fieldCode="AU" term="%22Guo+LS%22">Guo LS</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.<br /><searchLink fieldCode="AU" term="%22Liu+WY%22">Liu WY</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.<br /><searchLink fieldCode="AU" term="%22Liang+ZQ%22">Liang ZQ</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.<br /><searchLink fieldCode="AU" term="%22Yao+CS%22">Yao CS</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.<br /><searchLink fieldCode="AU" term="%22Wei+Y%22">Wei Y</searchLink>; Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.<br /><searchLink fieldCode="AU" term="%22Yue+X%22">Yue X</searchLink>; The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.<br /><searchLink fieldCode="AU" term="%22Mahmud+MRA%22">Mahmud MRA</searchLink>; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, United States.<br /><searchLink fieldCode="AU" term="%22Agama+K%22">Agama K</searchLink>; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, United States.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.<br /><searchLink fieldCode="AU" term="%22Pommier+Y%22">Pommier Y</searchLink>; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, United States.<br /><searchLink fieldCode="AU" term="%22An+LK%22">An LK</searchLink>; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou 510006, China. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 May 08; Vol. 68 (9), pp. 9323-9340. <i>Date of Electronic Publication: </i>2025 Apr 29. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40298128 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.jmedchem.4c02951 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 9323 Titles: – TitleFull: Synthesis of 5,9- and 5,8-Diaminoalkoxy Substituted Benzophenanthridinone Analogues as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors and Their Radiosensitizing Activity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hu DX – PersonEntity: Name: NameFull: Qin C – PersonEntity: Name: NameFull: Guo LS – PersonEntity: Name: NameFull: Liu WY – PersonEntity: Name: NameFull: Liang ZQ – PersonEntity: Name: NameFull: Cao Y – PersonEntity: Name: NameFull: Yao CS – PersonEntity: Name: NameFull: Wei Y – PersonEntity: Name: NameFull: Yue X – PersonEntity: Name: NameFull: Mahmud MRA – PersonEntity: Name: NameFull: Agama K – PersonEntity: Name: NameFull: Wang H – PersonEntity: Name: NameFull: Pommier Y – PersonEntity: Name: NameFull: An LK IsPartOfRelationships: – BibEntity: Dates: – D: 08 M: 05 Text: 2025 May 08 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 68 – Type: issue Value: 9 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
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