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Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9.

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Title: Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9.
Authors: Daniels MH; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Castro J; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Lee YT; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Gotur D; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Knockenhauer KE; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Grigoriu S; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Lockbaum GJ; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Cheong JE; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Lu C; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Brennan D; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Buker SM; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Liu J; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Yao S; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Sparling BA; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Sickmier EA; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Ribich S; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Blakemore SJ; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Silver SJ; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Boriack-Sjodin PA; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Duncan KW; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Copeland RA; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 May 08; Vol. 68 (9), pp. 9537-9554. Date of Electronic Publication: 2025 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.5c00252