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Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9.

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Title: Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9.
Authors: Daniels MH; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Castro J; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Lee YT; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Gotur D; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Knockenhauer KE; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Grigoriu S; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Lockbaum GJ; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Cheong JE; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Lu C; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Brennan D; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Buker SM; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Liu J; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Yao S; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Sparling BA; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Sickmier EA; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Ribich S; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Blakemore SJ; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Silver SJ; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Boriack-Sjodin PA; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Duncan KW; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States., Copeland RA; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 May 08; Vol. 68 (9), pp. 9537-9554. Date of Electronic Publication: 2025 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9.
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  Data: <searchLink fieldCode="AU" term="%22Daniels+MH%22">Daniels MH</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Castro+J%22">Castro J</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Lee+YT%22">Lee YT</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Gotur+D%22">Gotur D</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Knockenhauer+KE%22">Knockenhauer KE</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Grigoriu+S%22">Grigoriu S</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Lockbaum+GJ%22">Lockbaum GJ</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Cheong+JE%22">Cheong JE</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Lu+C%22">Lu C</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Brennan+D%22">Brennan D</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Buker+SM%22">Buker SM</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Yao+S%22">Yao S</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Sparling+BA%22">Sparling BA</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Sickmier+EA%22">Sickmier EA</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Ribich+S%22">Ribich S</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Blakemore+SJ%22">Blakemore SJ</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Silver+SJ%22">Silver SJ</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Boriack-Sjodin+PA%22">Boriack-Sjodin PA</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Duncan+KW%22">Duncan KW</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.<br /><searchLink fieldCode="AU" term="%22Copeland+RA%22">Copeland RA</searchLink>; Accent Therapeutics, Inc., 1050 Waltham Street, Lexington, Massachusetts 02421, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 May 08; Vol. 68 (9), pp. 9537-9554. <i>Date of Electronic Publication: </i>2025 Apr 29.
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        Value: 10.1021/acs.jmedchem.5c00252
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        Text: English
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              Text: 2025 May 08
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