Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival.
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| Title: | Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival. |
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| Authors: | Korleski J; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA.; Department of Internal Medicine, Mayo Clinic Rochester, Minnesota, USA., Sall S; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA., Luly KM; Department of Biomedical Engineering and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, USA., Johnson MK; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA.; Department of Biology, Johns Hopkins University, Baltimore, USA., Johnson AL; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA., Khela H; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA.; Department of Neuroscience, Johns Hopkins University, Baltimore, USA., Lal B; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA., Taylor TC; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA.; Department of Neuroscience, Johns Hopkins University, Baltimore, USA., Ashby JM; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA., Alonso H; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA., Li A; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA., Zhou W; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA., Smith-Connor K; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA., Hughes R; Single Cell & Transcriptomics Core at the Institute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, USA., Tzeng SY; Department of Biomedical Engineering and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, USA., Laterra J; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, USA., Green JJ; Department of Biomedical Engineering and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, USA. green@jhu.edu.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, USA. green@jhu.edu.; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, USA. green@jhu.edu.; Departments of Materials Science & Engineering and Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, USA. green@jhu.edu.; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA. green@jhu.edu.; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, USA. green@jhu.edu., Lopez-Bertoni H; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, USA. Lopezbertoni@kennedykrieger.org.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA. Lopezbertoni@kennedykrieger.org.; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, USA. Lopezbertoni@kennedykrieger.org. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2025 Apr 30; Vol. 10 (1), pp. 145. Date of Electronic Publication: 2025 Apr 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-025-02223-w |
