The Discovery and Characterization of HBS-101, a Novel Inhibitor of Midkine, as a Therapeutic Agent for the Treatment of Triple-Negative Breast Cancer.

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Title: The Discovery and Characterization of HBS-101, a Novel Inhibitor of Midkine, as a Therapeutic Agent for the Treatment of Triple-Negative Breast Cancer.
Authors: Mahajan M; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas., Rodriguez Sanchez AL; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas., Jayamohan S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas., Vijayan DK; Laboratory for Computational and Structural Biology, Jubilee Centre for Medical Research, Thrissur, India., Johnson JD; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas., Xie H; Department of Pharmaceutical Science, Texas Southern University, Houston, Texas., Wang Y; Department of Pharmaceutical Science, Texas Southern University, Houston, Texas., Liang D; Department of Pharmaceutical Science, Texas Southern University, Houston, Texas., Sanchez JR 2nd; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas., Subbarayalu P; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas.; Mays Cancer Center, San Antonio, Texas., Rao MK; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, Texas.; Mays Cancer Center, San Antonio, Texas., Vadlamudi RK; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas.; Mays Cancer Center, San Antonio, Texas.; Audie L. Murphy South Texas Veterans Health Care System, San Antonio, Texas., Sareddy GR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas.; Mays Cancer Center, San Antonio, Texas., Nair HB; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas., Viswanadhapalli S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas.; Mays Cancer Center, San Antonio, Texas.
Source: Molecular cancer therapeutics [Mol Cancer Ther] 2025 Sep 02; Vol. 24 (9), pp. 1308-1319.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-8514
DOI:10.1158/1535-7163.MCT-25-0130