The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study.

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Title: The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study.
Authors: Crandell J; Department of Immunobiology, Yale School of Medicine, Yale University, New Haven, CT, USA., Monteiro VS; Department of Immunobiology, Yale School of Medicine, Yale University, New Haven, CT, USA., Pischel L; Section of Infectious Diseases, Department of Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA., Fang Z; Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA; System Biology Institute, Yale University, West Haven, CT, USA; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA., Conde L; Department of Immunobiology, Yale School of Medicine, Yale University, New Haven, CT, USA., Zhong Y; Department of Immunobiology, Yale School of Medicine, Yale University, New Haven, CT, USA., Lawres L; Department of Immunobiology, Yale School of Medicine, Yale University, New Haven, CT, USA., de Asis GM; Laboratorio de Biologia de Linfócitos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Maciel G; Laboratorio de Biologia de Linfócitos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Zaleski A; Yale Center for Clinical Investigation, Yale University, New Haven, CT, USA., Lira GS; Departamento de Doenças Infecciosas e Parasitarias, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Higa LM; Departamento de Doenças Infecciosas e Parasitarias, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Breban MI; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Vogels CBF; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Caria J; Infectious Diseases Unit, Hospital de Curry Cabral, Unidade Local de Saúde São José, Lisbon, Portugal., Pinto AR; Infectious Diseases Unit, Hospital de Curry Cabral, Unidade Local de Saúde São José, Lisbon, Portugal., Almeida V; Infectious Diseases Unit, Hospital de Curry Cabral, Unidade Local de Saúde São José, Lisbon, Portugal., Maltez F; Infectious Diseases Unit, Hospital de Curry Cabral, Unidade Local de Saúde São José, Lisbon, Portugal; Instituto de Saúde Ambiental-Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal., Cordeiro R; Infectious Diseases Department, National Institute of Health Dr Ricardo Jorge, Lisbon, Portugal., Póvoas D; Infectious Diseases Unit, Hospital de Curry Cabral, Unidade Local de Saúde São José, Lisbon, Portugal; Lymphocyte Physiology, Instituto Gulbenkian de Ciência, Lisbon, Portugal., Grubaugh ND; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Aoun-Barakat L; Section of Infectious Diseases, Department of Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA., Grifoni A; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Sette A; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA; Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA, USA., Castineiras TM; Departamento de Doenças Infecciosas e Parasitarias, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Chen S; Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA; Comprehensive Cancer Center, Yale School of Medicine, Yale University, New Haven, CT, USA; Stem Cell Center, Yale School of Medicine, Yale University, New Haven, CT, USA; Center for Biomedical Data Science, Yale School of Medicine, Yale University, New Haven, CT, USA; System Biology Institute, Yale University, West Haven, CT, USA; Center for Cancer Systems Biology, Yale University, West Haven, CT, USA; Wu-Tsai Institute, Yale University, New Haven, CT, USA., Yildirim I; Yale Institute for Global Health, Yale University, New Haven, CT, USA; Center for Infection and Immunity, Yale University, New Haven, CT, USA; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA; Department of Pediatrics, Section of Infectious Diseases and Global Health, Yale School of Medicine, Yale University, New Haven, CT, USA., Vale AM; Laboratorio de Biologia de Linfócitos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Omer SB; Peter O'Donnell Jr School of Public Health, University of Texas Southwestern, Dallas, TX, USA., Lucas C; Department of Immunobiology, Yale School of Medicine, Yale University, New Haven, CT, USA; Center for Infection and Immunity, Yale University, New Haven, CT, USA. Electronic address: carolina.lucas@yale.edu.
Source: The Lancet. Microbe [Lancet Microbe] 2025 Jul; Vol. 6 (7), pp. 101098. Date of Electronic Publication: 2025 Apr 28.
Publication Type: Journal Article; Multicenter Study; Observational Study
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-5247
DOI:10.1016/j.lanmic.2025.101098