Rare genetic variation in PTPRB is associated with central serous chorioretinopathy, varicose veins and glaucoma.
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| Title: | Rare genetic variation in PTPRB is associated with central serous chorioretinopathy, varicose veins and glaucoma. |
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| Authors: | Rämö JT; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Massachusetts Eye and Ear, Boston, MA, USA.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Gorman BR; Center for Data and Computational Sciences (C-DACS), VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.; Booz Allen Hamilton, McLean, VA, USA., Weng LC; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Jurgens SJ; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Heart Failure & Arrhythmias, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Singhanetr P; Massachusetts Eye and Ear, Boston, MA, USA.; Mettapracharak Eye Institute, Mettapracharak (Wat Rai Khing) Hospital, Nakhon Pathom, Thailand., Tieger MG; New England Eye Center, Tufts Medical Center, Boston, MA, USA., van Dijk EH; Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands., Halladay CW; Center of Innovation in Long Term Services and Supports, Providence VA Medical Center, Providence, RI, USA., Wang X; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hauser BM; Massachusetts Eye and Ear, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Kim SH; Massachusetts Eye and Ear, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Brinks J; Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands., Choi SH; Department of Biostatistics, Boston University, Boston, MA, USA., Luo Y; Massachusetts Eye and Ear, Boston, MA, USA., Pyarajan S; VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard School of Medicine, Boston, MA, USA., Nealon CL; Eye Clinic, VA Northeast Ohio Healthcare System, Cleveland, OH, USA., Gorin MB; Department of Ophthalmology, David Geffen School of Medicine, Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA., Wu WC; Section of Cardiology, Medical Service, VA Providence Healthcare System, Providence, RI, USA., Anthony SA; Eye Clinic, VA Northeast Ohio Healthcare System, Cleveland, OH, USA., Roncone DP; Eye Clinic, VA Northeast Ohio Healthcare System, Cleveland, OH, USA., Sobrin L; Harvard Medical School Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA, USA., Kaarniranta K; Department of Ophthalmology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Yzer S; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., Palotie A; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Peachey NS; Research Service, VA Northeast Ohio Healthcare System, Cleveland, OH, USA.; Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA., Turunen JA; Folkhälsan Research Center, Biomedicum, Helsinki, Finland.; Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Boon CJ; Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Ophthalmology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Ellinor PT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Iyengar SK; Research Service, VA Northeast Ohio Healthcare System, Cleveland, OH, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Daly MJ; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rossin EJ; Harvard Medical School Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA, USA. elizabeth_rossin@meei.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. elizabeth_rossin@meei.harvard.edu. |
| Corporate Authors: | FinnGen, VA Million Veteran Program |
| Source: | Nature communications [Nat Commun] 2025 May 03; Vol. 16 (1), pp. 4127. Date of Electronic Publication: 2025 May 03. |
| Publication Type: | Journal Article; Meta-Analysis |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-58686-6 |
