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P-cadherin overexpression is associated with early transformation of the Fallopian tube epithelium and aggressiveness of tubo-ovarian high-grade serous carcinoma.

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Title: P-cadherin overexpression is associated with early transformation of the Fallopian tube epithelium and aggressiveness of tubo-ovarian high-grade serous carcinoma.
Authors: Canário R; Graduate Program in Areas of Basic and Applied Biology (GABBA), School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal.; Cancer Metastasis, i3S-Institute for Research and Innovation in Health, University of Porto, Porto, Portugal.; Cancer Biology and Epigenetics Group, Research Center-Portuguese Oncology Institute of Porto (CI-IPO-Porto)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca), Porto, Portugal.; Cancer Genetics Group, Research Center-Portuguese Oncology Institute of Porto (CI-IPO-Porto)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca), Porto, Portugal., Ribeiro AS; Cancer Metastasis, i3S-Institute for Research and Innovation in Health, University of Porto, Porto, Portugal., Morgado I; Cancer Metastasis, i3S-Institute for Research and Innovation in Health, University of Porto, Porto, Portugal., Peixoto A; Cancer Genetics Group, Research Center-Portuguese Oncology Institute of Porto (CI-IPO-Porto)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca), Porto, Portugal.; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO-Porto)/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca), Porto, Portugal., Barbosa A; Cancer Genetics Group, Research Center-Portuguese Oncology Institute of Porto (CI-IPO-Porto)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca), Porto, Portugal.; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO-Porto)/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca), Porto, Portugal., Santos C; Cancer Genetics Group, Research Center-Portuguese Oncology Institute of Porto (CI-IPO-Porto)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca), Porto, Portugal.; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO-Porto)/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca), Porto, Portugal., Mendes N; Histology and Electron Microscopy, i3S-Institute for Research and Innovation in Health, University of Porto, Porto, Portugal., Lopes P; Cancer Biology and Epigenetics Group, Research Center-Portuguese Oncology Institute of Porto (CI-IPO-Porto)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca), Porto, Portugal.; Pathology Department, Portuguese Oncology Institute of Porto (IPO-Porto)/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca) , Porto, Portugal., Monteiro P; Cancer Biology and Epigenetics Group, Research Center-Portuguese Oncology Institute of Porto (CI-IPO-Porto)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca), Porto, Portugal.; Pathology Department, Portuguese Oncology Institute of Porto (IPO-Porto)/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca) , Porto, Portugal., Coelho R; Ovarian Cancer Research, Department of Biomedicine, University Hospital Basel and University of Basel, 4031, Basel, Switzerland., Jacob F; Ovarian Cancer Research, Department of Biomedicine, University Hospital Basel and University of Basel, 4031, Basel, Switzerland., Heinzelmann-Schwarz V; Ovarian Cancer Research, Department of Biomedicine, University Hospital Basel and University of Basel, 4031, Basel, Switzerland., Ricardo S; Ageing and Stress Group, i3S-Institute for Research and Innovation in Health,, University of Porto, Porto, Portugal.; Associate Laboratory I4HB, Institute for Health and Bioeconomy, University Institute of Health Sciences-CESPU, Gandra, Portugal.; UCIBIO-Applied Molecular Biosciences Unit, Toxicologic Pathology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), Gandra, Portugal., Teixeira MR; Cancer Genetics Group, Research Center-Portuguese Oncology Institute of Porto (CI-IPO-Porto)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca), Porto, Portugal.; Department of Laboratory Genetics, Portuguese Oncology Institute of Porto (IPO-Porto)/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca), Porto, Portugal.; Pathology and Molecular Immunology Department, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal., Bartosch C; Cancer Biology and Epigenetics Group, Research Center-Portuguese Oncology Institute of Porto (CI-IPO-Porto)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca), Porto, Portugal.; Pathology Department, Portuguese Oncology Institute of Porto (IPO-Porto)/Porto. Comprehensive Cancer Center Raquel Seruca (P.CCC Raquel Seruca) , Porto, Portugal.; Pathology and Molecular Immunology Department, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal., Paredes J; Cancer Metastasis, i3S-Institute for Research and Innovation in Health, University of Porto, Porto, Portugal. jparedes@i3s.up.pt.; FMUP-Faculty of Medicine, University of Porto, Porto, Portugal. jparedes@i3s.up.pt.
Source: Virchows Archiv : an international journal of pathology [Virchows Arch] 2026 Feb; Vol. 488 (2), pp. 309-323. Date of Electronic Publication: 2025 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 9423843 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2307 (Electronic) Linking ISSN: 09456317 NLM ISO Abbreviation: Virchows Arch Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1432-2307
DOI:10.1007/s00428-025-04104-7