Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness.

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Title: Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness.
Authors: Meena D; Department of Epidemiology and Biostatistics, Imperial College London School of Public Health, London, UK., Huang J; Department of Epidemiology and Biostatistics, Imperial College London School of Public Health, London, UK., Zare M; Maternal-fetal medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Hasbani NR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Romuald BP; Clinical Research Unit of Nanoro, Institut de Recherche en Sciences de la Santé, CNRST, Burkina Faso., Mustafa R; Department of Epidemiology and Biostatistics, Imperial College London School of Public Health, London, UK., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Xu H; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Terry JG; Department of Radiology, Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Jain D; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Heard-Costa N; Boston University School of Medicine, Boston, MA, USA.; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA., Min YI; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Tan J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Peralta J; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Pereira AC; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of S√£o Paulo, S√£o Paulo, Brazil., Khan A; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Choudhury A; Division of Human Genetics at the National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa., Newman AB; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Xiang AH; Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA USA., Hingorani A; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, United Kingdom., Freedman BI; Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., O'Donnell CJ; VA Boston Healthcare System, West Roxbury VA Medical Center, Cardiology Section, Boston, MA, USA., Giambartolomei C; Department of Pathology and Laboratory Medicine, University of California (UCLA), Los Angeles, Los Angeles, CA, USA., Herrington DM; Department of Internal Medicine, Section of Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., Jacobs DR Jr; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA., Klarin D; VA Palo Alto Healthcare System, Palo Alto, CA.; Department of Surgery, Stanford University Medical Center, Stanford, CA., Wang FF; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Heiss G; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Doddapaneni H; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Hodis HN; Department of Preventive Medicine, Department of Medicine, Atherosclerosis Research Unit, Keck School of Medicine, University of Southern California, Los Angeles, CA USA., Broome J; Genetic Analysis Center, Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Wilson JG; Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA., Brandenburg JT; Division of Human Genetics at the National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa., Blangero J; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Krieger JE; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of S√£o Paulo, S√£o Paulo, Brazil., Smith JD; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Northwest Genomics Center, University of Washington, Seattle, WA, USA., Viaud-Martinez KA; Illumina Laboratory Services, Illumina Inc., San Diego, CA, USA., Ryan KA; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Lange LA; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Montasser ME; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Mahaney MC; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Mokry M; Laboratory of Experimental Cardiology, Department of Cardiology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands., Fornage M; Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., Munroe P; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, UK.; NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, UK., Gibbs RA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Tracy RP; Department of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT, USA., Kim RW; Psomagen Inc., Rockville, MD, USA., Damrauer SM; Division of Vascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA., Rich SS; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Hsueh WA; Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Mitchell BD; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Carr JJ; Department of Radiology, Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Vasan RS; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA., Correa A; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA., Post WS; Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Goodarzi MO; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA USA., Raffel LJ; Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, CA USA., Curran JE; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Ramsay M; Division of Human Genetics at the National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Elliott P; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.; UK Dementia Research Institute, Imperial College London, London UK.; National Institute for Health Research Imperial College Biomedical Research Centre, Imperial College London, London, UK., Franceschini N; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Tzoulaki I; Department of Epidemiology and Biostatistics, Imperial College London School of Public Health, London, UK.; British Heart Foundation Centre of Excellence, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina, Ioannina, Greece., Dehghan A; Department of Epidemiology and Biostatistics, Imperial College London School of Public Health, London, UK.
Corporate Authors: NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, The Million Veteran Program (MVP), TOPMed Atherosclerosis Working Group
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Apr 14. Date of Electronic Publication: 2025 Apr 14.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2025.04.11.25325582