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Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis.

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Title: Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis.
Authors: Zhang HJ; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Zhao Q; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Zhang M; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Yang LL; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Abiti J; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Han MM; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Gao YP; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Lu JT; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Wang JN; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Ji MY; School of Basic Medicine, Xinxiang Medical University, Xinxiang 453003, Henan, China., Zhang X; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Wang W; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Qiu LL; School of Basic Medicine, Xinxiang Medical University, Xinxiang 453003, Henan, China., Wang XY; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang 453003, Henan, China., Wang TY; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang 453003, Henan, China., Jia YL; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.
Source: ACS synthetic biology [ACS Synth Biol] 2025 May 16; Vol. 14 (5), pp. 1802-1812. Date of Electronic Publication: 2025 May 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101575075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2161-5063 (Electronic) Linking ISSN: 21615063 NLM ISO Abbreviation: ACS Synth Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2161-5063
DOI:10.1021/acssynbio.5c00161