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Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis.

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Title: Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis.
Authors: Zhang HJ; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Zhao Q; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Zhang M; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Yang LL; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Abiti J; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Han MM; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Gao YP; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Lu JT; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Wang JN; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Ji MY; School of Basic Medicine, Xinxiang Medical University, Xinxiang 453003, Henan, China., Zhang X; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Wang W; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China., Qiu LL; School of Basic Medicine, Xinxiang Medical University, Xinxiang 453003, Henan, China., Wang XY; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang 453003, Henan, China., Wang TY; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang 453003, Henan, China., Jia YL; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.
Source: ACS synthetic biology [ACS Synth Biol] 2025 May 16; Vol. 14 (5), pp. 1802-1812. Date of Electronic Publication: 2025 May 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101575075 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2161-5063 (Electronic) Linking ISSN: 21615063 NLM ISO Abbreviation: ACS Synth Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+HJ%22">Zhang HJ</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Q%22">Zhao Q</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.<br /><searchLink fieldCode="AU" term="%22Yang+LL%22">Yang LL</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.<br /><searchLink fieldCode="AU" term="%22Abiti+J%22">Abiti J</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.<br /><searchLink fieldCode="AU" term="%22Han+MM%22">Han MM</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.<br /><searchLink fieldCode="AU" term="%22Gao+YP%22">Gao YP</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.<br /><searchLink fieldCode="AU" term="%22Lu+JT%22">Lu JT</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.<br /><searchLink fieldCode="AU" term="%22Wang+JN%22">Wang JN</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.<br /><searchLink fieldCode="AU" term="%22Ji+MY%22">Ji MY</searchLink>; School of Basic Medicine, Xinxiang Medical University, Xinxiang 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.<br /><searchLink fieldCode="AU" term="%22Qiu+LL%22">Qiu LL</searchLink>; School of Basic Medicine, Xinxiang Medical University, Xinxiang 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Wang+XY%22">Wang XY</searchLink>; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Wang+TY%22">Wang TY</searchLink>; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang 453003, Henan, China.<br /><searchLink fieldCode="AU" term="%22Jia+YL%22">Jia YL</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China 453003.; International Joint Laboratory of Recombinant Drug Protein Expression System, Xinxiang, Henan China, 453003.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan 453003, China.
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  Data: <searchLink fieldCode="JN" term="%22101575075%22">ACS synthetic biology</searchLink> [ACS Synth Biol] 2025 May 16; Vol. 14 (5), pp. 1802-1812. <i>Date of Electronic Publication: </i>2025 May 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101575075 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2161-5063 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221615063%22">21615063 </searchLink><i>NLM ISO Abbreviation: </i>ACS Synth Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acssynbio.5c00161
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