OTUD1 positively regulates microglia neuroinflammation and promotes the pathogenesis of Alzheimer's disease by deubiquitinating C/EBPβ.

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Title: OTUD1 positively regulates microglia neuroinflammation and promotes the pathogenesis of Alzheimer's disease by deubiquitinating C/EBPβ.
Authors: She LY; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China., Li LY; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China., Tang H; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China., Yu Q; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China., Gao FY; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China., Zeng YQ; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China., Chen LJ; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China., Xiong L; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China., Li LW; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China., Chen F; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China., Sun JF; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, 133002, China., Zheng WH; Center of Reproduction, Development and Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau, 999078, China., Zhao X; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. xiazhao@hmc.edu.cn.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. xiazhao@hmc.edu.cn.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China. xiazhao@hmc.edu.cn., Liang G; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. wzmcliangguang@163.com.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. wzmcliangguang@163.com.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China. wzmcliangguang@163.com.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Oct; Vol. 46 (10), pp. 2608-2621. Date of Electronic Publication: 2025 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-7254
DOI:10.1038/s41401-025-01566-y