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OTUD1 positively regulates microglia neuroinflammation and promotes the pathogenesis of Alzheimer's disease by deubiquitinating C/EBPβ.

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Title: OTUD1 positively regulates microglia neuroinflammation and promotes the pathogenesis of Alzheimer's disease by deubiquitinating C/EBPβ.
Authors: She LY; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China., Li LY; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China., Tang H; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China., Yu Q; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China., Gao FY; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China., Zeng YQ; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China., Chen LJ; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China., Xiong L; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China., Li LW; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China., Chen F; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China., Sun JF; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, 133002, China., Zheng WH; Center of Reproduction, Development and Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau, 999078, China., Zhao X; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. xiazhao@hmc.edu.cn.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. xiazhao@hmc.edu.cn.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China. xiazhao@hmc.edu.cn., Liang G; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. wzmcliangguang@163.com.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. wzmcliangguang@163.com.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China. wzmcliangguang@163.com.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Oct; Vol. 46 (10), pp. 2608-2621. Date of Electronic Publication: 2025 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: OTUD1 positively regulates microglia neuroinflammation and promotes the pathogenesis of Alzheimer's disease by deubiquitinating C/EBPβ.
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  Data: <searchLink fieldCode="AU" term="%22She+LY%22">She LY</searchLink>; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China.<br /><searchLink fieldCode="AU" term="%22Li+LY%22">Li LY</searchLink>; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.<br /><searchLink fieldCode="AU" term="%22Tang+H%22">Tang H</searchLink>; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China.<br /><searchLink fieldCode="AU" term="%22Yu+Q%22">Yu Q</searchLink>; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.<br /><searchLink fieldCode="AU" term="%22Gao+FY%22">Gao FY</searchLink>; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.<br /><searchLink fieldCode="AU" term="%22Zeng+YQ%22">Zeng YQ</searchLink>; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.<br /><searchLink fieldCode="AU" term="%22Chen+LJ%22">Chen LJ</searchLink>; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.<br /><searchLink fieldCode="AU" term="%22Xiong+L%22">Xiong L</searchLink>; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China.<br /><searchLink fieldCode="AU" term="%22Li+LW%22">Li LW</searchLink>; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China.<br /><searchLink fieldCode="AU" term="%22Sun+JF%22">Sun JF</searchLink>; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China.; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji, 133002, China.<br /><searchLink fieldCode="AU" term="%22Zheng+WH%22">Zheng WH</searchLink>; Center of Reproduction, Development and Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau, 999078, China.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. xiazhao@hmc.edu.cn.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. xiazhao@hmc.edu.cn.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China. xiazhao@hmc.edu.cn.<br /><searchLink fieldCode="AU" term="%22Liang+G%22">Liang G</searchLink>; The First People's Hospital of Lin'an District, Affiliated Lin'an People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. wzmcliangguang@163.com.; Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. wzmcliangguang@163.com.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, 311399, China. wzmcliangguang@163.com.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2025 Oct; Vol. 46 (10), pp. 2608-2621. <i>Date of Electronic Publication: </i>2025 May 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100956087 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-7254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216714083%22">16714083 </searchLink><i>NLM ISO Abbreviation: </i>Acta Pharmacol Sin <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41401-025-01566-y
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        Text: English
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      – TitleFull: OTUD1 positively regulates microglia neuroinflammation and promotes the pathogenesis of Alzheimer's disease by deubiquitinating C/EBPβ.
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