The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer.

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Title: The Immunomechanical Checkpoint PYK2 Governs Monocyte-to-Macrophage Differentiation in Pancreatic Cancer.
Authors: Xie W; State Key Laboratory of Biotherapy, Department of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Yu X; State Key Laboratory of Biotherapy, Department of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Yang Q; State Key Laboratory of Biotherapy, Department of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Ke N; Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, China., Wang P; State Key Laboratory of Biotherapy, Department of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Kong H; State Key Laboratory of Biotherapy, Department of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Wu X; State Key Laboratory of Biotherapy, Department of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Ma P; Department of Surgical Oncology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China., Chen L; Department of Surgical Oncology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China., Yang J; Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, China., Feng X; State Key Laboratory of Biotherapy, Department of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Wang Y; State Key Laboratory of Biotherapy, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China., Shi H; State Key Laboratory of Biotherapy, Institute for Breast Health Medicine, West China Hospital, Sichuan University, Chengdu, China., Chen L; Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, China., Liu YH; Department of Surgical Oncology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, China., Ding BS; Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, China., Wei Q; College of Polymer Science and Engineering, National Key Laboratory of Advanced Polymer, Sichuan University, Chengdu, China., Jiang H; State Key Laboratory of Biotherapy, Department of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.; Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Source: Cancer discovery [Cancer Discov] 2025 Aug 04; Vol. 15 (8), pp. 1740-1765.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2159-8290
DOI:10.1158/2159-8290.CD-24-1712