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Highly conserved brain vascular receptor ALPL mediates transport of engineered AAV vectors across the blood-brain barrier.

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Title: Highly conserved brain vascular receptor ALPL mediates transport of engineered AAV vectors across the blood-brain barrier.
Authors: Moyer TC; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Hoffman BA; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Chen W; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Shah I; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Ren XQ; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Knox T; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Liu J; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Wang W; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Li J; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Khalid H; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Kulkarni AS; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Egbuchulam M; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Clement J; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Bloedel A; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Child M; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Kaur R; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Rouse E; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Graham K; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Maura D; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Thorpe Z; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Sayed-Zahid A; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Hiu-Yan Chung C; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Kutchin A; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Johnson A; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Yao J; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Thompson J; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Pande N; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Nonnenmacher ME; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA. Electronic address: mnonnenmacher@vygr.com.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Aug 06; Vol. 33 (8), pp. 3902-3916. Date of Electronic Publication: 2025 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-0024
DOI:10.1016/j.ymthe.2025.04.046