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Highly conserved brain vascular receptor ALPL mediates transport of engineered AAV vectors across the blood-brain barrier.

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Title: Highly conserved brain vascular receptor ALPL mediates transport of engineered AAV vectors across the blood-brain barrier.
Authors: Moyer TC; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Hoffman BA; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Chen W; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Shah I; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Ren XQ; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Knox T; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Liu J; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Wang W; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Li J; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Khalid H; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Kulkarni AS; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Egbuchulam M; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Clement J; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Bloedel A; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Child M; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Kaur R; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Rouse E; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Graham K; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Maura D; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Thorpe Z; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Sayed-Zahid A; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Hiu-Yan Chung C; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Kutchin A; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Johnson A; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Yao J; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Thompson J; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Pande N; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA., Nonnenmacher ME; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA. Electronic address: mnonnenmacher@vygr.com.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Aug 06; Vol. 33 (8), pp. 3902-3916. Date of Electronic Publication: 2025 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Highly conserved brain vascular receptor ALPL mediates transport of engineered AAV vectors across the blood-brain barrier.
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  Data: <searchLink fieldCode="AU" term="%22Moyer+TC%22">Moyer TC</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Hoffman+BA%22">Hoffman BA</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Shah+I%22">Shah I</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Ren+XQ%22">Ren XQ</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Knox+T%22">Knox T</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Khalid+H%22">Khalid H</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Kulkarni+AS%22">Kulkarni AS</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Egbuchulam+M%22">Egbuchulam M</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Clement+J%22">Clement J</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Bloedel+A%22">Bloedel A</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Child+M%22">Child M</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Kaur+R%22">Kaur R</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Rouse+E%22">Rouse E</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Graham+K%22">Graham K</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Maura+D%22">Maura D</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Thorpe+Z%22">Thorpe Z</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Sayed-Zahid+A%22">Sayed-Zahid A</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Hiu-Yan+Chung+C%22">Hiu-Yan Chung C</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Kutchin+A%22">Kutchin A</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+A%22">Johnson A</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Yao+J%22">Yao J</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+J%22">Thompson J</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Pande+N%22">Pande N</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA.<br /><searchLink fieldCode="AU" term="%22Nonnenmacher+ME%22">Nonnenmacher ME</searchLink>; Voyager Therapeutics, 75 Hayden Avenue, Lexington, MA 02421, USA. Electronic address: mnonnenmacher@vygr.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100890581 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1525-0024 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215250016%22">15250016 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther <i>Subsets: </i>MEDLINE
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