Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma.
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| Title: | Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma. |
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| Authors: | Shinozaki T; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Togasaki K; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.; Department of Gastroenterology, Keio University, School of Medicine, Tokyo, Japan., Hamamoto J; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Mitsuishi A; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Fukushima T; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Sugihara K; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Ebisudani T; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan., Okada M; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Saito A; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Shigematsu L; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Takaoka H; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Ito F; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Ohgino K; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Ishioka K; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Watanabe K; Department of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan., Hishima T; Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan., Kurebayashi Y; Department of Pathology, Keio University School of Medicine, Tokyo, Japan., Emoto K; Department of Pathology, Keio University School of Medicine, Tokyo, Japan., Terai H; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Ikemura S; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Kawada I; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Asakura K; Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan., Hishida T; Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan., Asamura H; Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan., Ohta Y; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan., Takahashi S; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan., Oda M; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan., Saito M; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.; Otsuka Pharmaceutical Company Limited, Department of Drug Modality Development, Osaka Research Center for Drug Discovery, Osaka, Japan., Matano M; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan., Soejima K; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Fujii M; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan., Fukunaga K; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Yasuda H; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan. hiroyukiyasuda@keio.jp., Sato T; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan. t.sato@keio.jp.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan. t.sato@keio.jp. |
| Source: | Nature communications [Nat Commun] 2025 May 11; Vol. 16 (1), pp. 4369. Date of Electronic Publication: 2025 May 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-59623-3 |
