Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma.
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| Title: | Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma. |
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| Authors: | Shinozaki T; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Togasaki K; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.; Department of Gastroenterology, Keio University, School of Medicine, Tokyo, Japan., Hamamoto J; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Mitsuishi A; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Fukushima T; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Sugihara K; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Ebisudani T; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan., Okada M; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Saito A; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Shigematsu L; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Takaoka H; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Ito F; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Ohgino K; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Ishioka K; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Watanabe K; Department of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan., Hishima T; Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan., Kurebayashi Y; Department of Pathology, Keio University School of Medicine, Tokyo, Japan., Emoto K; Department of Pathology, Keio University School of Medicine, Tokyo, Japan., Terai H; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Ikemura S; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Kawada I; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Asakura K; Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan., Hishida T; Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan., Asamura H; Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan., Ohta Y; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan., Takahashi S; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan., Oda M; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan., Saito M; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.; Otsuka Pharmaceutical Company Limited, Department of Drug Modality Development, Osaka Research Center for Drug Discovery, Osaka, Japan., Matano M; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan., Soejima K; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Fujii M; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan., Fukunaga K; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan., Yasuda H; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan. hiroyukiyasuda@keio.jp., Sato T; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan. t.sato@keio.jp.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan. t.sato@keio.jp. |
| Source: | Nature communications [Nat Commun] 2025 May 11; Vol. 16 (1), pp. 4369. Date of Electronic Publication: 2025 May 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40350470 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Shinozaki+T%22">Shinozaki T</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Togasaki+K%22">Togasaki K</searchLink>; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.; Department of Gastroenterology, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hamamoto+J%22">Hamamoto J</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Mitsuishi+A%22">Mitsuishi A</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Fukushima+T%22">Fukushima T</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sugihara+K%22">Sugihara K</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ebisudani+T%22">Ebisudani T</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Okada+M%22">Okada M</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+A%22">Saito A</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shigematsu+L%22">Shigematsu L</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Takaoka+H%22">Takaoka H</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+F%22">Ito F</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ohgino+K%22">Ohgino K</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ishioka+K%22">Ishioka K</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+K%22">Watanabe K</searchLink>; Department of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hishima+T%22">Hishima T</searchLink>; Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kurebayashi+Y%22">Kurebayashi Y</searchLink>; Department of Pathology, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Emoto+K%22">Emoto K</searchLink>; Department of Pathology, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Terai+H%22">Terai H</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ikemura+S%22">Ikemura S</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kawada+I%22">Kawada I</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Asakura+K%22">Asakura K</searchLink>; Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hishida+T%22">Hishida T</searchLink>; Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Asamura+H%22">Asamura H</searchLink>; Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ohta+Y%22">Ohta Y</searchLink>; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+S%22">Takahashi S</searchLink>; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Oda+M%22">Oda M</searchLink>; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+M%22">Saito M</searchLink>; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.; Otsuka Pharmaceutical Company Limited, Department of Drug Modality Development, Osaka Research Center for Drug Discovery, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Matano+M%22">Matano M</searchLink>; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Soejima+K%22">Soejima K</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Fujii+M%22">Fujii M</searchLink>; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Fukunaga+K%22">Fukunaga K</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yasuda+H%22">Yasuda H</searchLink>; Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan. hiroyukiyasuda@keio.jp.<br /><searchLink fieldCode="AU" term="%22Sato+T%22">Sato T</searchLink>; Department of Integrative Medicine and Biochemistry, Keio University School of Medicine, Tokyo, Japan. t.sato@keio.jp.; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan. t.sato@keio.jp. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 May 11; Vol. 16 (1), pp. 4369. <i>Date of Electronic Publication: </i>2025 May 11. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
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