A novel approach for modeling in vivo enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase.
Saved in:
| Title: | A novel approach for modeling in vivo enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase. |
|---|---|
| Authors: | Volpi T; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Holden D; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Gallezot JD; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Nabulsi N; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Lim K; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Labaree D; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Gao H; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Kapinos M; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Keliher EJ; Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA., Fonseca KR; Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA., Trapa P; Drug Metabolism and Pharmacokinetics, Biogen, Cambridge, MA, USA., Varrone A; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden., Halldin C; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.; Department of Biophysics and Radiation Biology, and HUN-REN TKI, Semmelweis University, Budapest, Hungary., Maresca KP; Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA., Huang Y; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Carson RE; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA. |
| Source: | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2025 Oct; Vol. 45 (10), pp. 1947-1960. Date of Electronic Publication: 2025 May 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| ISSN: | 1559-7016 |
|---|---|
| DOI: | 10.1177/0271678X251329254 |
