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A novel approach for modeling in vivo enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase.

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Title: A novel approach for modeling in vivo enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase.
Authors: Volpi T; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Holden D; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Gallezot JD; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Nabulsi N; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Lim K; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Labaree D; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Gao H; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Kapinos M; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Keliher EJ; Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA., Fonseca KR; Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA., Trapa P; Drug Metabolism and Pharmacokinetics, Biogen, Cambridge, MA, USA., Varrone A; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden., Halldin C; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.; Department of Biophysics and Radiation Biology, and HUN-REN TKI, Semmelweis University, Budapest, Hungary., Maresca KP; Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA., Huang Y; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA., Carson RE; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA.
Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2025 Oct; Vol. 45 (10), pp. 1947-1960. Date of Electronic Publication: 2025 May 15.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Volpi+T%22">Volpi T</searchLink>; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Holden+D%22">Holden D</searchLink>; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Gallezot+JD%22">Gallezot JD</searchLink>; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Nabulsi+N%22">Nabulsi N</searchLink>; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Lim+K%22">Lim K</searchLink>; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Labaree+D%22">Labaree D</searchLink>; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Gao+H%22">Gao H</searchLink>; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Kapinos+M%22">Kapinos M</searchLink>; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Keliher+EJ%22">Keliher EJ</searchLink>; Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fonseca+KR%22">Fonseca KR</searchLink>; Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Trapa+P%22">Trapa P</searchLink>; Drug Metabolism and Pharmacokinetics, Biogen, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Varrone+A%22">Varrone A</searchLink>; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Halldin+C%22">Halldin C</searchLink>; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.; Department of Biophysics and Radiation Biology, and HUN-REN TKI, Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Maresca+KP%22">Maresca KP</searchLink>; Worldwide Research and Development, Pfizer Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Carson+RE%22">Carson RE</searchLink>; Department of Radiology and Biomedical Imaging, PET Center, Yale University, New Haven, CT, USA.
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