MARCH8 suppresses hepatocellular carcinoma by promoting SREBP1 degradation and modulating fatty acid de novo synthesis.

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Title: MARCH8 suppresses hepatocellular carcinoma by promoting SREBP1 degradation and modulating fatty acid de novo synthesis.
Authors: Tu DY; Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China., Peng R; Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China., Jin SJ; Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.; General Surgery Institute of Northern Jiangsu People's Hospital, Yangzhou, China., Su BB; Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China., Fan SS; Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China., Zhang JH; Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China., Wang SY; Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China., Miao YY; Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China., Jiang GQ; Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.; General Surgery Institute of Northern Jiangsu People's Hospital, Yangzhou, China., Zhang C; Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China. zc17212850@163.com.; General Surgery Institute of Northern Jiangsu People's Hospital, Yangzhou, China. zc17212850@163.com., Cao J; Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China. 18175709398@163.com.; General Surgery Institute of Northern Jiangsu People's Hospital, Yangzhou, China. 18175709398@163.com., Bai DS; Department of Hepatobiliary Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China. drbaidousheng@yzu.edu.cn.; General Surgery Institute of Northern Jiangsu People's Hospital, Yangzhou, China. drbaidousheng@yzu.edu.cn.
Source: Cell death & disease [Cell Death Dis] 2025 May 16; Vol. 16 (1), pp. 391. Date of Electronic Publication: 2025 May 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-025-07707-9