Durable T cell immunity to COVID-19 vaccines in MS patients on B cell depletion therapy.

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Title: Durable T cell immunity to COVID-19 vaccines in MS patients on B cell depletion therapy.
Authors: Davis-Porada J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY, USA., Tozlu C; Department of Radiology, Weill Cornell Medicine, New York, NY, USA., Aiello C; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Medical Scientist Training Program, Columbia University Irving Medical Center, New York, NY, USA., Apostolidis SA; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Division of Rheumatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bar-Or A; Center for Neuroinflammation and Experimental Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bove R; UCSF Weill Institute for Neuroscience, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Espinoza DA; Center for Neuroinflammation and Experimental Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ferreira Brito S; Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, Neurology, Columbia Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, New York, NY, USA., Jacobs D; Center for Neuroinflammation and Experimental Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Kakara M; Department of Neurology, NYU Grossman School of Medicine, New York, NY, USA., Onomichi K; Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, Neurology, Columbia Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, New York, NY, USA., Ricci A; Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, Neurology, Columbia Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, New York, NY, USA., Sabatino JJ Jr; UCSF Weill Institute for Neuroscience, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Walker E; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Wherry EJ; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Zhang L; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Zhu W; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Xia Z; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., De Jager P; Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, Neurology, Columbia Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, New York, NY, USA., Wesley SF; Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, Neurology, Columbia Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, New York, NY, USA. sfw2116@cumc.columbia.edu., Straus Farber R; Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, Neurology, Columbia Multiple Sclerosis Center and Center for Translational & Computational Neuroimmunology, New York, NY, USA. rs3648@cumc.columbia.edu., Farber DL; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu.; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu.
Source: NPJ vaccines [NPJ Vaccines] 2025 May 17; Vol. 10 (1), pp. 98. Date of Electronic Publication: 2025 May 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature in partnership with the Sealy Center for Vaccine Development Country of Publication: England NLM ID: 101699863 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-0105 (Electronic) Linking ISSN: 20590105 NLM ISO Abbreviation: NPJ Vaccines Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2059-0105
DOI:10.1038/s41541-025-01151-8