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Senkyunolide A mitigates lipid deposition in hyperlipidemic hepatocytes through SIRT6-mediated suppression of oxidative stress and fetuin-A.

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Title: Senkyunolide A mitigates lipid deposition in hyperlipidemic hepatocytes through SIRT6-mediated suppression of oxidative stress and fetuin-A.
Authors: Ko JH; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Republic of Korea., Jung TW; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea., Pyo MK; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Republic of Korea., Lim DS; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Republic of Korea., Gwon HJ; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Republic of Korea., Abd El-Aty AM; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt; Department of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum, 25240, Turkey. Electronic address: abdelaty44@hotmail.com., Yağan R; Dr. Filiz Dolunay Family Health Center Unit Number:61 Erzurum, Turkey., Shin JW; Department of Internal Medicine, Division of Allergy and Respiratory Medicine, Chung-Ang University, Seoul, Republic of Korea., Lee MY; Department of Physiology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea., Song JH; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea. Electronic address: jinhos@cau.ac.kr., Jeong JH; Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, Republic of Korea. Electronic address: jhjeong3@cau.ac.kr.
Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Jul 22; Vol. 771, pp. 152046. Date of Electronic Publication: 2025 May 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1090-2104
DOI:10.1016/j.bbrc.2025.152046